Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904229604> ?p ?o ?g. }
- W2904229604 abstract "Abstract Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans. However, genome-wide studies of the effects of STRs on gene expression thus far have had limited power to detect associations and provide insights into putative mechanisms. Here, we leverage whole genome sequencing and expression data for 17 tissues from the Genotype-Tissue Expression Project (GTEx) to identify STRs for which repeat number is associated with expression of nearby genes (eSTRs). Our analysis reveals more than 28,000 eSTRs. We employ fine-mapping to quantify the probability that each eSTR is causal and characterize a group of the top 1,400 fine-mapped eSTRs. We identify hundreds of eSTRs linked with published GWAS signals and implicate specific eSTRs in complex traits including height and schizophrenia, inflammatory bowel disease, and intelligence. Overall, our results support the hypothesis that eSTRs contribute to a range of human phenotypes and will serve as a valuable resource for future studies of complex traits." @default.
- W2904229604 created "2018-12-22" @default.
- W2904229604 creator A5006479263 @default.
- W2904229604 creator A5008291058 @default.
- W2904229604 creator A5018749704 @default.
- W2904229604 creator A5039817862 @default.
- W2904229604 creator A5040271672 @default.
- W2904229604 creator A5052276107 @default.
- W2904229604 creator A5065055599 @default.
- W2904229604 creator A5078684080 @default.
- W2904229604 date "2018-12-13" @default.
- W2904229604 modified "2023-09-27" @default.
- W2904229604 title "Multi-tissue analysis reveals short tandem repeats as ubiquitous regulators of gene expression and complex traits" @default.
- W2904229604 cites W1605145036 @default.
- W2904229604 cites W1653978584 @default.
- W2904229604 cites W1971104826 @default.
- W2904229604 cites W1980973068 @default.
- W2904229604 cites W1981041672 @default.
- W2904229604 cites W1982092236 @default.
- W2904229604 cites W1983792907 @default.
- W2904229604 cites W1986911601 @default.
- W2904229604 cites W1989298969 @default.
- W2904229604 cites W1992436001 @default.
- W2904229604 cites W2001280003 @default.
- W2904229604 cites W2014677321 @default.
- W2904229604 cites W2015139247 @default.
- W2904229604 cites W2021042620 @default.
- W2904229604 cites W2021191052 @default.
- W2904229604 cites W2025943989 @default.
- W2904229604 cites W2029355185 @default.
- W2904229604 cites W2029874784 @default.
- W2904229604 cites W2043257091 @default.
- W2904229604 cites W2069545688 @default.
- W2904229604 cites W2071551577 @default.
- W2904229604 cites W2076359272 @default.
- W2904229604 cites W2081944144 @default.
- W2904229604 cites W2092863749 @default.
- W2904229604 cites W2101357408 @default.
- W2904229604 cites W2101505979 @default.
- W2904229604 cites W2102406302 @default.
- W2904229604 cites W2102619694 @default.
- W2904229604 cites W2104549677 @default.
- W2904229604 cites W2105153745 @default.
- W2904229604 cites W2108169091 @default.
- W2904229604 cites W2111826500 @default.
- W2904229604 cites W2114161957 @default.
- W2904229604 cites W2124561138 @default.
- W2904229604 cites W2128016314 @default.
- W2904229604 cites W2131173813 @default.
- W2904229604 cites W2136273720 @default.
- W2904229604 cites W2137746159 @default.
- W2904229604 cites W2139739374 @default.
- W2904229604 cites W2140272554 @default.
- W2904229604 cites W2141157874 @default.
- W2904229604 cites W2146949579 @default.
- W2904229604 cites W2147643191 @default.
- W2904229604 cites W2149459456 @default.
- W2904229604 cites W2152325859 @default.
- W2904229604 cites W2154518334 @default.
- W2904229604 cites W2157752701 @default.
- W2904229604 cites W2161633633 @default.
- W2904229604 cites W2163328995 @default.
- W2904229604 cites W2181523240 @default.
- W2904229604 cites W2209106767 @default.
- W2904229604 cites W2227356030 @default.
- W2904229604 cites W2255138985 @default.
- W2904229604 cites W2259344468 @default.
- W2904229604 cites W2264585211 @default.
- W2904229604 cites W2277896056 @default.
- W2904229604 cites W2328393125 @default.
- W2904229604 cites W2330659059 @default.
- W2904229604 cites W2520605819 @default.
- W2904229604 cites W2520749639 @default.
- W2904229604 cites W2559028527 @default.
- W2904229604 cites W2609153336 @default.
- W2904229604 cites W2616090912 @default.
- W2904229604 cites W2684631428 @default.
- W2904229604 cites W2724938313 @default.
- W2904229604 cites W2725988230 @default.
- W2904229604 cites W2761275051 @default.
- W2904229604 cites W2785429866 @default.
- W2904229604 cites W2790166063 @default.
- W2904229604 cites W2809193491 @default.
- W2904229604 cites W2949884285 @default.
- W2904229604 cites W2950818041 @default.
- W2904229604 cites W2951079876 @default.
- W2904229604 cites W2951856336 @default.
- W2904229604 cites W2952113787 @default.
- W2904229604 cites W2952679261 @default.
- W2904229604 doi "https://doi.org/10.1101/495226" @default.
- W2904229604 hasPublicationYear "2018" @default.
- W2904229604 type Work @default.
- W2904229604 sameAs 2904229604 @default.
- W2904229604 citedByCount "3" @default.
- W2904229604 countsByYear W29042296042019 @default.
- W2904229604 countsByYear W29042296042020 @default.
- W2904229604 crossrefType "posted-content" @default.
- W2904229604 hasAuthorship W2904229604A5006479263 @default.
- W2904229604 hasAuthorship W2904229604A5008291058 @default.
- W2904229604 hasAuthorship W2904229604A5018749704 @default.