Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904230112> ?p ?o ?g. }
- W2904230112 startingPage "498543" @default.
- W2904230112 abstract "In eukaryotes, conserved mechanisms ensure that cell growth is coordinated with nutrient availability. Overactive growth during nutrient limitation leads to rapid cell death. Here, we demonstrate that cells can adapt to this nutrient-growth imbalance by evolving major metabolic defects. Specifically, when yeast lysine auxotrophic mutant lys- suffered nutrient-growth imbalance in limited lysine, a sub-population repeatedly evolved to lose the ability to synthesize organosulfurs (lys-orgS-). Organosulfurs, mainly glutathione and glutathione conjugates, were released by lys- cells during lysine limitation when nutrient-growth is imbalanced, but not during glucose limitation when nutrient-growth is balanced. Limiting organosulfurs conferred a frequency-dependent fitness advantage to lys-orgS- by eliciting a proper slow growth program including autophagy. Thus, nutrient-growth imbalance can trigger rapid niche construction, which in turn enables the selection of an overt metabolic defect to better tune cell growth to the metabolic environment." @default.
- W2904230112 created "2018-12-22" @default.
- W2904230112 creator A5001393755 @default.
- W2904230112 creator A5003316821 @default.
- W2904230112 creator A5033461529 @default.
- W2904230112 creator A5033692642 @default.
- W2904230112 creator A5053275663 @default.
- W2904230112 creator A5053467552 @default.
- W2904230112 creator A5058650629 @default.
- W2904230112 creator A5071275598 @default.
- W2904230112 creator A5075542698 @default.
- W2904230112 creator A5080702347 @default.
- W2904230112 creator A5083110402 @default.
- W2904230112 creator A5084107608 @default.
- W2904230112 date "2018-12-17" @default.
- W2904230112 modified "2023-10-03" @default.
- W2904230112 title "Rapid evolution of an overt metabolic defect restores balanced growth" @default.
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