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• W2904232429 endingPage "45" @default.
• W2904232429 startingPage "34" @default.
• W2904232429 abstract "Reptiles are ancestral organisms presenting a variety of shapes, from the elongated vertebral column of the snake to the turtle dorsalized ribs or retractile neck. Body plans are specified by a conserved group of homeobox-containing genes (<i>Hox</i> genes), which encode transcription factors important in cell fate and vertebral architecture along the anteroposterior axis during embryonic development; thus, dysregulation of these genes may cause congenital malformations, from mild-sublethal to embryonic-lethal. The genetic pool, maternal transfer, and environmental conditions during egg incubation affect development; environmental factors such as temperature, moisture, oxygen, and pollution may alter gene expression by epigenetic mechanisms. Thus, in this review, we present information regarding <i>Hox</i> genes and development in reptiles, including sex determination and teratogenesis. We also present some evidence of epigenetic regulation of <i>Hox</i> genes and the role of the environment in epigenetic modulation of gene expression. So far, the evidence suggests that the molecular instructions encoded by <i>Hox</i> genes to build a snake, a lizard, or a turtle represent the interplay between genome and epigenome after years of evolution, with occasional environmentally induced molecular mistakes leading to abnormal body shapes." @default.
• W2904232429 created "2018-12-22" @default.
• W2904232429 creator A5080741808 @default.
• W2904232429 creator A5080856570 @default.
• W2904232429 creator A5083259741 @default.
• W2904232429 date "2018-12-15" @default.
• W2904232429 modified "2023-10-18" @default.
• W2904232429 title "<b><i>Hox</i></b> Genes in Reptile Development, Epigenetic Regulation, and Teratogenesis" @default.
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