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- W2904232877 abstract "Purpose of review This review highlights current knowledge on the dichotomous role played by T helper 17 cells (Th17)-polarized CD4+ T cells in maintaining mucosal immunity homeostasis versus fueling HIV/simian immunodeficiency virus (SIV) replication/persistence during antiretroviral therapy (ART), with a focus on molecular mechanisms underlying these processes. Recent finding Th17 cells bridge innate and adaptive immunity against pathogens at mucosal barrier surfaces. Th17 cells are located at portal sites of HIV/SIV entry, express a unique transcriptional/metabolic status compatible with viral replication, and represent the first targets of infection. The paucity of Th17 cells during HIV/SIV infection is caused by infection itself, but also by an altered Th17 differentiation, survival, and trafficking into mucosal sites. This causes major alterations of mucosal barrier integrity, microbial translocation, and disease progression. Unless initiated during the early acute infection phases, ART fails to restore the frequency/functionality of mucosal Th17 cells. A fraction of Th17 cells is long-lived and carry HIV reservoir during ART. Recent studies identified Th17-specific host factors controlling HIV transcription, a step untargeted by current ART. Summary The identification of molecular mechanisms contributing to HIV replication/persistence in mucosal Th17 cells paves the way toward the design of new Th17-specific therapeutic strategies aimed at improving mucosal immunity in HIV-infected individuals." @default.
- W2904232877 created "2018-12-22" @default.
- W2904232877 creator A5036431603 @default.
- W2904232877 creator A5038607718 @default.
- W2904232877 creator A5044251474 @default.
- W2904232877 date "2019-03-01" @default.
- W2904232877 modified "2023-10-01" @default.
- W2904232877 title "New Th17-specific therapeutic strategies for HIV remission" @default.
- W2904232877 cites W1005468862 @default.
- W2904232877 cites W1187448213 @default.
- W2904232877 cites W1554976296 @default.
- W2904232877 cites W1605790011 @default.
- W2904232877 cites W1624461902 @default.
- W2904232877 cites W1748436622 @default.
- W2904232877 cites W1749946895 @default.
- W2904232877 cites W1893048652 @default.
- W2904232877 cites W1966226308 @default.
- W2904232877 cites W1972960900 @default.
- W2904232877 cites W1983484396 @default.
- W2904232877 cites W1988435860 @default.
- W2904232877 cites W2003664178 @default.
- W2904232877 cites W2015230022 @default.
- W2904232877 cites W2016488838 @default.
- W2904232877 cites W2017520700 @default.
- W2904232877 cites W2020122175 @default.
- W2904232877 cites W2022104434 @default.
- W2904232877 cites W2028362556 @default.
- W2904232877 cites W2029016685 @default.
- W2904232877 cites W2031551895 @default.
- W2904232877 cites W2031697684 @default.
- W2904232877 cites W2031959283 @default.
- W2904232877 cites W2033327108 @default.
- W2904232877 cites W2034202667 @default.
- W2904232877 cites W2053550293 @default.
- W2904232877 cites W2058983339 @default.
- W2904232877 cites W2064140898 @default.
- W2904232877 cites W2065958240 @default.
- W2904232877 cites W2077531651 @default.
- W2904232877 cites W2077914568 @default.
- W2904232877 cites W2078489697 @default.
- W2904232877 cites W2084533546 @default.
- W2904232877 cites W2097227023 @default.
- W2904232877 cites W2099845413 @default.
- W2904232877 cites W2101266783 @default.
- W2904232877 cites W2103065132 @default.
- W2904232877 cites W2106894610 @default.
- W2904232877 cites W2121449768 @default.
- W2904232877 cites W2124571773 @default.
- W2904232877 cites W2152390002 @default.
- W2904232877 cites W2161722835 @default.
- W2904232877 cites W2162805528 @default.
- W2904232877 cites W2162805842 @default.
- W2904232877 cites W2186116877 @default.
- W2904232877 cites W2191255018 @default.
- W2904232877 cites W2212811500 @default.
- W2904232877 cites W2236519749 @default.
- W2904232877 cites W2263584512 @default.
- W2904232877 cites W2275746341 @default.
- W2904232877 cites W2313088707 @default.
- W2904232877 cites W2321660288 @default.
- W2904232877 cites W2333804036 @default.
- W2904232877 cites W2336017858 @default.
- W2904232877 cites W2347802084 @default.
- W2904232877 cites W2411771969 @default.
- W2904232877 cites W2418599563 @default.
- W2904232877 cites W2427560245 @default.
- W2904232877 cites W2462036387 @default.
- W2904232877 cites W2509511970 @default.
- W2904232877 cites W2517479804 @default.
- W2904232877 cites W2531054429 @default.
- W2904232877 cites W2554913814 @default.
- W2904232877 cites W2555744616 @default.
- W2904232877 cites W2564084609 @default.
- W2904232877 cites W2572467248 @default.
- W2904232877 cites W2593149781 @default.
- W2904232877 cites W2607084817 @default.
- W2904232877 cites W2616875005 @default.
- W2904232877 cites W2619565046 @default.
- W2904232877 cites W2622166486 @default.
- W2904232877 cites W2740538710 @default.
- W2904232877 cites W2753183473 @default.
- W2904232877 cites W2755216414 @default.
- W2904232877 cites W2756020839 @default.
- W2904232877 cites W2762486448 @default.
- W2904232877 cites W2769830302 @default.
- W2904232877 cites W2779934443 @default.
- W2904232877 cites W2786546763 @default.
- W2904232877 cites W2789111316 @default.
- W2904232877 cites W2789395632 @default.
- W2904232877 cites W2791875436 @default.
- W2904232877 cites W2792293236 @default.
- W2904232877 cites W2806775299 @default.
- W2904232877 cites W2808531824 @default.
- W2904232877 cites W2843664023 @default.
- W2904232877 cites W2883423117 @default.
- W2904232877 cites W2884579947 @default.
- W2904232877 cites W2885329409 @default.
- W2904232877 cites W2885448955 @default.