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• W2904234976 endingPage "181303" @default.
• W2904234976 startingPage "181303" @default.
• W2904234976 abstract "The Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of FUCCI-expressing HeLa cells (FUCCI-HeLa cells) and monitored the cell cycle in individual live cells over time by determining the ratios between red fluorescence (RF) of RFP-Cdt1 and green fluorescence (GF) of GFP-Geminin. Cytotoxic and cytostatic compounds, the latter of which induced G2 or mitotic arrest, were identified based on periodic cycling of the RF/GF and GF/RF ratios in FUCCI-HeLa cells treated with anti-cancer drugs. With this cell cycle monitoring system, ten flavonoids were screened. Of these, apigenin and luteolin, which have a flavone backbone, were cytotoxic, whereas kaempferol, which has a flavonol backbone, was cytostatic and induced G2 arrest. In summary, we developed a system to quantitatively monitor the cell cycle in real time. This system can be used to identify novel compounds that modulate the cell cycle and to investigate structure–activity relationships." @default.
• W2904234976 created "2018-12-22" @default.
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• W2904234976 date "2018-12-01" @default.
• W2904234976 modified "2023-10-16" @default.
• W2904234976 title "Screening of cytotoxic or cytostatic flavonoids with quantitative Fluorescent Ubiquitination-based Cell Cycle Indicator-based cell cycle assay" @default.
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• W2904234976 doi "https://doi.org/10.1098/rsos.181303" @default.
• W2904234976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6304118" @default.
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• W2904234976 hasPublicationYear "2018" @default.
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