Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904237875> ?p ?o ?g. }
- W2904237875 endingPage "46" @default.
- W2904237875 startingPage "37" @default.
- W2904237875 abstract "Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer's disease. We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefrontal cortices; in contrast with amyloid-β, tau protein burden had a broad effect on the epigenome, affecting 5,990 of 26,384 H3K9ac domains. Tau-related alterations aggregated in large genomic segments reflecting spatial chromatin organization, and the magnitude of these effects correlated with the segment's nuclear lamina association. Functional relevance of these chromatin changes was demonstrated by (1) consistent transcriptional changes in three independent datasets and (2) similar findings in two mouse models of Alzheimer's disease. Finally, we found that tau overexpression in induced pluripotent stem cell-derived neurons altered chromatin structure and that these effects could be blocked by a small molecule predicted to reverse the tau effect. Thus, we report broad tau-driven chromatin rearrangements in the aging human brain that may be reversible with heat-shock protein 90 (Hsp90) inhibitors." @default.
- W2904237875 created "2018-12-22" @default.
- W2904237875 creator A5004634867 @default.
- W2904237875 creator A5014075642 @default.
- W2904237875 creator A5019701579 @default.
- W2904237875 creator A5021329449 @default.
- W2904237875 creator A5022605809 @default.
- W2904237875 creator A5031703305 @default.
- W2904237875 creator A5035831050 @default.
- W2904237875 creator A5040310665 @default.
- W2904237875 creator A5042440695 @default.
- W2904237875 creator A5049324919 @default.
- W2904237875 creator A5058470461 @default.
- W2904237875 creator A5065367298 @default.
- W2904237875 creator A5073421716 @default.
- W2904237875 creator A5075431238 @default.
- W2904237875 creator A5079371001 @default.
- W2904237875 creator A5087205945 @default.
- W2904237875 creator A5087425115 @default.
- W2904237875 date "2018-12-17" @default.
- W2904237875 modified "2023-10-16" @default.
- W2904237875 title "Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains" @default.
- W2904237875 cites W1887325245 @default.
- W2904237875 cites W1896708637 @default.
- W2904237875 cites W1969874328 @default.
- W2904237875 cites W1991244004 @default.
- W2904237875 cites W1997866877 @default.
- W2904237875 cites W1999574084 @default.
- W2904237875 cites W2002659179 @default.
- W2904237875 cites W2006588853 @default.
- W2904237875 cites W2040027262 @default.
- W2904237875 cites W2044962871 @default.
- W2904237875 cites W2057249855 @default.
- W2904237875 cites W2060444097 @default.
- W2904237875 cites W2060820956 @default.
- W2904237875 cites W2063540863 @default.
- W2904237875 cites W2076154138 @default.
- W2904237875 cites W2080477348 @default.
- W2904237875 cites W2081098333 @default.
- W2904237875 cites W2090037139 @default.
- W2904237875 cites W2090384073 @default.
- W2904237875 cites W2096317307 @default.
- W2904237875 cites W2097798909 @default.
- W2904237875 cites W2103441770 @default.
- W2904237875 cites W2111940674 @default.
- W2904237875 cites W2114525505 @default.
- W2904237875 cites W2115779804 @default.
- W2904237875 cites W2117757143 @default.
- W2904237875 cites W2119519240 @default.
- W2904237875 cites W2121604817 @default.
- W2904237875 cites W2124514674 @default.
- W2904237875 cites W2125805216 @default.
- W2904237875 cites W2130523009 @default.
- W2904237875 cites W2133174470 @default.
- W2904237875 cites W2135374418 @default.
- W2904237875 cites W2137526110 @default.
- W2904237875 cites W2145909463 @default.
- W2904237875 cites W2152664025 @default.
- W2904237875 cites W2155888201 @default.
- W2904237875 cites W2156124720 @default.
- W2904237875 cites W2158226173 @default.
- W2904237875 cites W2170314963 @default.
- W2904237875 cites W2170989872 @default.
- W2904237875 cites W2171808845 @default.
- W2904237875 cites W2191292005 @default.
- W2904237875 cites W2203120038 @default.
- W2904237875 cites W2460504496 @default.
- W2904237875 cites W2507676175 @default.
- W2904237875 cites W2514975062 @default.
- W2904237875 cites W2531904292 @default.
- W2904237875 cites W2534005127 @default.
- W2904237875 cites W2791286257 @default.
- W2904237875 cites W2804633924 @default.
- W2904237875 cites W648684004 @default.
- W2904237875 doi "https://doi.org/10.1038/s41593-018-0291-1" @default.
- W2904237875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6516529" @default.
- W2904237875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30559478" @default.
- W2904237875 hasPublicationYear "2018" @default.
- W2904237875 type Work @default.
- W2904237875 sameAs 2904237875 @default.
- W2904237875 citedByCount "163" @default.
- W2904237875 countsByYear W29042378752019 @default.
- W2904237875 countsByYear W29042378752020 @default.
- W2904237875 countsByYear W29042378752021 @default.
- W2904237875 countsByYear W29042378752022 @default.
- W2904237875 countsByYear W29042378752023 @default.
- W2904237875 crossrefType "journal-article" @default.
- W2904237875 hasAuthorship W2904237875A5004634867 @default.
- W2904237875 hasAuthorship W2904237875A5014075642 @default.
- W2904237875 hasAuthorship W2904237875A5019701579 @default.
- W2904237875 hasAuthorship W2904237875A5021329449 @default.
- W2904237875 hasAuthorship W2904237875A5022605809 @default.
- W2904237875 hasAuthorship W2904237875A5031703305 @default.
- W2904237875 hasAuthorship W2904237875A5035831050 @default.
- W2904237875 hasAuthorship W2904237875A5040310665 @default.
- W2904237875 hasAuthorship W2904237875A5042440695 @default.
- W2904237875 hasAuthorship W2904237875A5049324919 @default.
- W2904237875 hasAuthorship W2904237875A5058470461 @default.