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• W2904238789 endingPage "39" @default.
• W2904238789 startingPage "25" @default.
• W2904238789 abstract "Cerebral autoregulatory dysfunction after traumatic brain injury (TBI) is strongly linked to poor global outcome in patients at 6 months after injury. However, our understanding of the drivers of this dysfunction is limited. Genetic variation among individuals within a population gives rise to single-nucleotide polymorphisms (SNPs) that have the potential to influence a given patient’s cerebrovascular response to an injury. Associations have been reported between a variety of genetic polymorphisms and global outcome in patients with TBI, but few studies have explored the association between genetic variants and cerebrovascular function after injury. In this Review, we explore polymorphisms that might play an important part in cerebral autoregulatory capacity after TBI. We outline a variety of SNPs, their biological substrates and their potential role in mediating cerebrovascular reactivity. A number of candidate polymorphisms exist in genes that are involved in myogenic, endothelial, metabolic and neurogenic vascular responses to injury. Furthermore, polymorphisms in genes involved in inflammation, the central autonomic response and cortical spreading depression might drive cerebrovascular reactivity. Identification of candidate genes involved in cerebral autoregulation after TBI provides a platform and rationale for further prospective investigation of the link between genetic polymorphisms and autoregulatory function. Impairment of cerebral autoregulation after traumatic brain injury (TBI) is associated with poor outcomes, but the reasons underlying this association are poorly understood. This Review highlights genetic polymorphisms that might be linked to cerebrovascular function after TBI that might promote improved understanding of the pathogenic mechanisms underlying impaired vascular reactivity and offer potential targets for new therapies." @default.
• W2904238789 created "2018-12-22" @default.
• W2904238789 creator A5044517183 @default.
• W2904238789 creator A5057778218 @default.
• W2904238789 creator A5063616994 @default.
• W2904238789 creator A5064523646 @default.
• W2904238789 creator A5066855601 @default.
• W2904238789 creator A5066924372 @default.
• W2904238789 creator A5082953939 @default.
• W2904238789 creator A5086027330 @default.
• W2904238789 date "2018-12-13" @default.
• W2904238789 modified "2023-10-17" @default.
• W2904238789 title "Genetic drivers of cerebral blood flow dysfunction in TBI: a speculative synthesis" @default.
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