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- W2904239243 abstract "Objective: Adiposity, not blood pressure (BP), is associated with left ventricular hypertrophy (LVH) among hypertensive children without chronic kidney disease (CKD). We aimed to determine the longitudinal association of BMI z-score with LVH and left ventricular mass index (LVMI) among children with CKD. Methods: 696 participants of the Chronic Kidney Disease in Children study with echocardiography results who contributed a total of 1,300 visits were included. Mixed models, adjusting for repeated visits with a random subject effect, were used to determine the longitudinal association of body mass index (BMI) z-score with LVMI and LVH (LVMI> age-sex specific 95 th %ile). Models were adjusted for age, sex, race, systolic and diastolic BP z-score, glomerular diagnosis, time with CKD, glomerular filtration rate and calcium*phosphorus product and accounted for informative censoring. Results: Baseline characteristics are in the table. Among females, a 1 unit increase in BMI z-score was associated with an 8.5% increase in LVMI and 3.4 greater odds of LVH, whereas with boys, a 1 unit increase in BMI z-score was associated with a 5.2% increase in LVMI and a 1.4 greater odds of LVH (p<0.05 for all). Conclusions: Among children with mild-moderate CKD, adiposity is independently associated with LVMI and LVH over time. This association is greater among females, a finding that may have future clinical and research implications." @default.
- W2904239243 created "2018-12-22" @default.
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- W2904239243 date "2018-09-01" @default.
- W2904239243 modified "2023-10-16" @default.
- W2904239243 title "Abstract P393: Sex Modifies the Longitudinal Association of Adiposity With Left Ventricular Hypertrophy Among Children With Chronic Kidney Disease" @default.
- W2904239243 doi "https://doi.org/10.1161/hyp.72.suppl_1.p393" @default.
- W2904239243 hasPublicationYear "2018" @default.
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