FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904248836> ?p ?o ?g. }

• W2904248836 endingPage "101644" @default.
• W2904248836 startingPage "101644" @default.
• W2904248836 abstract "Akinesia is a major manifestation of Parkinson's disease (PD) related to difficulties or failures of willed movement to occur. Akinesia is still poorly understood and is not fully alleviated by standard therapeutic strategies. One reason is that the area of the clinical concept has blurred boundaries referring to confounded motor symptoms. Here, we review neuroimaging studies which, by providing access to finer-grained mechanisms, have the potential to reveal the dysfunctional brain processes that account for akinesia. It comes out that no clear common denominator could be identified across studies that are too heterogeneous with respect to the clinical/theoretical concepts and methods used. Results reveal, however, that various abnormalities within but also outside the motor and dopaminergic pathways might be associated with akinesia in PD patients. Notably, numerous yet poorly reproducible neural correlates were found in different brain regions supporting executive control by means of resting-state or task-based studies. This includes for instance the dorsolateral prefrontal cortex, the inferior frontal cortex, the supplementary motor area, the medial prefrontal cortex, the anterior cingulate cortex or the precuneus. This observation raises the issue of the multidimensional nature of akinesia. Yet, other open issues should be considered conjointly to drive future investigations. Above all, a unified terminology is needed to allow appropriate association of behavioral symptoms with brain mechanisms across studies. We adhere to a use of the term akinesia restricted to dysfunctions of movement initiation, ranging from delayed response to freezing or even total abolition of movement. We also call for targeting more specific neural mechanisms of movement preparation and action triggering with more sophisticated behavioral designs/event-related neurofunctional analyses. More work is needed to provide reliable evidence, but answering these still open issues might open up new prospects, beyond dopaminergic therapy, for managing this disabling symptom." @default.
• W2904248836 created "2018-12-22" @default.
• W2904248836 creator A5011216618 @default.
• W2904248836 creator A5024230337 @default.
• W2904248836 creator A5049205840 @default.
• W2904248836 creator A5071738567 @default.
• W2904248836 creator A5072737817 @default.
• W2904248836 creator A5074012261 @default.
• W2904248836 date "2019-01-01" @default.
• W2904248836 modified "2023-10-05" @default.
• W2904248836 title "Functional imaging correlates of akinesia in Parkinson's disease: Still open issues" @default.
• W2904248836 cites W1526783251 @default.
• W2904248836 cites W169782504 @default.
• W2904248836 cites W1834193729 @default.
• W2904248836 cites W1940166213 @default.
• W2904248836 cites W1966024827 @default.
• W2904248836 cites W1966525408 @default.
• W2904248836 cites W1971246980 @default.
• W2904248836 cites W1972038286 @default.
• W2904248836 cites W1978776771 @default.
• W2904248836 cites W1981123646 @default.
• W2904248836 cites W1982827121 @default.
• W2904248836 cites W1983238487 @default.
• W2904248836 cites W1986352677 @default.
• W2904248836 cites W1987055966 @default.
• W2904248836 cites W1997008008 @default.
• W2904248836 cites W1999385317 @default.
• W2904248836 cites W2002314838 @default.
• W2904248836 cites W2004996958 @default.
• W2904248836 cites W2009706073 @default.
• W2904248836 cites W2013990856 @default.
• W2904248836 cites W2015113560 @default.
• W2904248836 cites W2017472757 @default.
• W2904248836 cites W2025849843 @default.
• W2904248836 cites W2026949786 @default.
• W2904248836 cites W2027346623 @default.
• W2904248836 cites W2029087300 @default.
• W2904248836 cites W2031170958 @default.
• W2904248836 cites W2044940345 @default.
• W2904248836 cites W2050430957 @default.
• W2904248836 cites W2050540607 @default.
• W2904248836 cites W2051413433 @default.
• W2904248836 cites W2055832690 @default.
• W2904248836 cites W2058481315 @default.
• W2904248836 cites W2064469175 @default.
• W2904248836 cites W2068250382 @default.
• W2904248836 cites W2072522618 @default.
• W2904248836 cites W2072646528 @default.
• W2904248836 cites W2076597270 @default.
• W2904248836 cites W2077737902 @default.
• W2904248836 cites W2079355604 @default.
• W2904248836 cites W2081425074 @default.
• W2904248836 cites W2082391125 @default.
• W2904248836 cites W2085101987 @default.
• W2904248836 cites W2087598124 @default.
• W2904248836 cites W2088373257 @default.
• W2904248836 cites W2089574993 @default.
• W2904248836 cites W2089906028 @default.
• W2904248836 cites W2091558603 @default.
• W2904248836 cites W2093533434 @default.
• W2904248836 cites W2097641938 @default.
• W2904248836 cites W2100958431 @default.
• W2904248836 cites W2103906241 @default.
• W2904248836 cites W2103939873 @default.
• W2904248836 cites W2104033295 @default.
• W2904248836 cites W2106108170 @default.
• W2904248836 cites W2106147981 @default.
• W2904248836 cites W2111893944 @default.
• W2904248836 cites W2117381358 @default.
• W2904248836 cites W2120835420 @default.
• W2904248836 cites W2124517301 @default.
• W2904248836 cites W2127478702 @default.
• W2904248836 cites W2129922948 @default.
• W2904248836 cites W2130974692 @default.
• W2904248836 cites W2139126801 @default.
• W2904248836 cites W2140309190 @default.
• W2904248836 cites W2140374231 @default.
• W2904248836 cites W2145039080 @default.
• W2904248836 cites W2145758129 @default.
• W2904248836 cites W2152316935 @default.
• W2904248836 cites W2152874468 @default.
• W2904248836 cites W2158359335 @default.
• W2904248836 cites W2158625734 @default.
• W2904248836 cites W2168283435 @default.
• W2904248836 cites W2169443648 @default.
• W2904248836 cites W2256669593 @default.
• W2904248836 cites W2260750747 @default.
• W2904248836 cites W2291457528 @default.
• W2904248836 cites W2312244472 @default.
• W2904248836 cites W2316347809 @default.
• W2904248836 cites W2317061090 @default.
• W2904248836 cites W2339776301 @default.
• W2904248836 cites W2347197552 @default.
• W2904248836 cites W2406736647 @default.
• W2904248836 cites W2412169208 @default.
• W2904248836 cites W2469366252 @default.
• W2904248836 cites W2529004207 @default.
• W2904248836 cites W2554118502 @default.

• next