Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904251155> ?p ?o ?g. }
- W2904251155 abstract "Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and contribute to biofilm formation, thereby promoting bacterial resistance to environmental stressors. Here, we present crystal structures of amyloid-forming segments from the major curlin subunit, CsgA, revealing steric zipper fibrils of tightly mated β-sheets, demonstrating a structural link between curli and human pathological amyloids. We propose that these cross-β segments structure the highly robust curli amyloid core. D-enantiomeric peptides, originally developed to interfere with Alzheimer's disease-associated Amyloid-β, inhibited CsgA fibrillation and reduced biofilm formation in Salmonella typhimurium. Moreover, CsgA fibrils cross-seeded fibrillation of Amyloid-β, providing further support for the proposed structural resemblance and potential for cross-species amyloid interactions. In this study, we provide structural insights into curli formation, offer a novel strategy for disrupting amyloid-structured biofilms, and hypothesize on the formation of self-propagating prion-like species originating from a microbial source that could influence neurodegenerative diseases." @default.
- W2904251155 created "2018-12-22" @default.
- W2904251155 creator A5003278326 @default.
- W2904251155 creator A5008126342 @default.
- W2904251155 creator A5016227275 @default.
- W2904251155 creator A5024642832 @default.
- W2904251155 creator A5027671970 @default.
- W2904251155 creator A5091222035 @default.
- W2904251155 creator A5091520561 @default.
- W2904251155 date "2018-12-11" @default.
- W2904251155 modified "2023-10-18" @default.
- W2904251155 title "Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspired Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents" @default.
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