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• W2904253189 abstract "Despite significant advances in the understanding of the therapeutic activity of antidepressant drugs, treatment-resistant depression is a public health issue prompting research to identify new therapeutic strategies. Evidence strongly suggests that nutrition might exert a significant impact on the onset, the duration and the severity of major depression. Accordingly, preclinical and clinical investigations demonstrated the beneficial effects of omega-3 fatty acids in anxiety and mood disorders. Although the neurobiological substrates of its action remain poorly documented, basic research has shown that omega-3 increases brain-derived neurotrophic factor (BDNF) levels in brain regions associated with depression, as antidepressant drugs do. In contrast, low BDNF levels and hippocampal atrophy were observed in animal models of depression. In this context, the present study compared the effects of long-lasting fish oil-enriched diet, an important source of omega-3 fatty acids, between heterozygous BDNF+/- mice and their wild-type littermates. Our results demonstrated lower activation of Erk in BDNF+/- mice whereas this deficit was rescued by fish oil-enriched diet. In parallel, BDNF+/- mice displayed elevated hippocampal extracellular 5-HT levels in relation with a local decreased serotonin transporter protein level. Fish oil-enriched diet restored normal serotonergic tone by increasing the protein levels of serotonin transporter. At the cellular level, fish oil-enriched diet increased the pool of immature neurons in the dentate gyrus of BDNF+/- mice and the latter observations coincide with its ability to promote anxiolytic- and antidepressant-like response in these mutants. Collectively, our results demonstrate that the beneficial effects of long-term exposure to fish oil-enriched diet in behavioral paradigms known to recapitulate diverse abnormalities related to the depressive state specifically in mice with a partial loss of BDNF. These findings contrast with the mechanism of action of currently available antidepressant drugs for which the full manifestation of their therapeutic activity depends on the enhancement of serotoninergic and BDNF signaling. Further studies are warranted to determine whether fish oil supplementation could be used as an add-on strategy to conventional pharmacological interventions in treatment-resistant patients and relevant animal models." @default.
• W2904253189 created "2018-12-22" @default.
• W2904253189 creator A5005859255 @default.
• W2904253189 creator A5012191518 @default.
• W2904253189 creator A5021449339 @default.
• W2904253189 creator A5034626388 @default.
• W2904253189 creator A5056801799 @default.
• W2904253189 creator A5084251667 @default.
• W2904253189 creator A5090646451 @default.
• W2904253189 date "2018-12-21" @default.
• W2904253189 modified "2023-10-16" @default.
• W2904253189 title "Anxiolytic- and Antidepressant-Like Effects of Fish Oil-Enriched Diet in Brain-Derived Neurotrophic Factor Deficient Mice" @default.
• W2904253189 cites W1499836217 @default.
• W2904253189 cites W1514296823 @default.
• W2904253189 cites W1556200960 @default.
• W2904253189 cites W1593725384 @default.
• W2904253189 cites W1625243294 @default.
• W2904253189 cites W1710423957 @default.
• W2904253189 cites W1827980384 @default.
• W2904253189 cites W1850225444 @default.
• W2904253189 cites W1916800927 @default.
• W2904253189 cites W1917884859 @default.
• W2904253189 cites W1967421959 @default.
• W2904253189 cites W1970080160 @default.
• W2904253189 cites W1971954112 @default.
• W2904253189 cites W1973418455 @default.
• W2904253189 cites W1974112092 @default.
• W2904253189 cites W1974583970 @default.
• W2904253189 cites W1975037391 @default.
• W2904253189 cites W1978282844 @default.
• W2904253189 cites W1979125819 @default.
• W2904253189 cites W1979468734 @default.
• W2904253189 cites W1981306895 @default.
• W2904253189 cites W1983706324 @default.
• W2904253189 cites W1986373853 @default.
• W2904253189 cites W1988424224 @default.
• W2904253189 cites W1989873406 @default.
• W2904253189 cites W1993278041 @default.
• W2904253189 cites W1993899508 @default.
• W2904253189 cites W1996447644 @default.
• W2904253189 cites W1999068011 @default.
• W2904253189 cites W2001053592 @default.
• W2904253189 cites W2002669733 @default.
• W2904253189 cites W2003494755 @default.
• W2904253189 cites W2003982930 @default.
• W2904253189 cites W2010291328 @default.
• W2904253189 cites W2014193054 @default.
• W2904253189 cites W2019054752 @default.
• W2904253189 cites W2022352764 @default.
• W2904253189 cites W2027787677 @default.
• W2904253189 cites W2028977103 @default.
• W2904253189 cites W2030081504 @default.
• W2904253189 cites W2032456267 @default.
• W2904253189 cites W2035862236 @default.
• W2904253189 cites W2043652950 @default.
• W2904253189 cites W2049036332 @default.
• W2904253189 cites W2049546073 @default.
• W2904253189 cites W2049837513 @default.
• W2904253189 cites W2055018912 @default.
• W2904253189 cites W2057953498 @default.
• W2904253189 cites W2061881919 @default.
• W2904253189 cites W2062195428 @default.
• W2904253189 cites W2066838264 @default.
• W2904253189 cites W2069184109 @default.
• W2904253189 cites W2069369539 @default.
• W2904253189 cites W2070058327 @default.
• W2904253189 cites W2072457730 @default.
• W2904253189 cites W2074663801 @default.
• W2904253189 cites W2074698464 @default.
• W2904253189 cites W2074868853 @default.
• W2904253189 cites W2076856384 @default.
• W2904253189 cites W2076894554 @default.
• W2904253189 cites W2078035790 @default.
• W2904253189 cites W2078335108 @default.
• W2904253189 cites W2078678809 @default.
• W2904253189 cites W2079841860 @default.
• W2904253189 cites W2082179080 @default.
• W2904253189 cites W2083673805 @default.
• W2904253189 cites W2088275762 @default.
• W2904253189 cites W2089036448 @default.
• W2904253189 cites W2089606257 @default.
• W2904253189 cites W2091927578 @default.
• W2904253189 cites W2097168654 @default.
• W2904253189 cites W2100685978 @default.
• W2904253189 cites W2101644352 @default.
• W2904253189 cites W2106095564 @default.
• W2904253189 cites W2109066629 @default.
• W2904253189 cites W2111443630 @default.
• W2904253189 cites W2117155939 @default.
• W2904253189 cites W2120804535 @default.
• W2904253189 cites W2121651624 @default.
• W2904253189 cites W2122664538 @default.
• W2904253189 cites W2123482365 @default.
• W2904253189 cites W2124333083 @default.
• W2904253189 cites W2126795224 @default.
• W2904253189 cites W2127718726 @default.
• W2904253189 cites W2128175779 @default.
• W2904253189 cites W2130125636 @default.
• W2904253189 cites W2132167094 @default.
• W2904253189 cites W2135016146 @default.

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