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• W2904253190 abstract "Abstract Understanding the patterns and genesis of germline de novo mutations is important for studying genome evolution and human diseases. Nucleosome organization is suggested to be a contributing factor to mutation rate variation across the genome. However, the small number of published de novo mutations and the low resolution of earlier nucleosome maps limited our understanding of how nucleosome organization affects germline mutation rates in the human genome. Here, we systematically investigated the relationship between nucleosome organization and fine-scale mutation rate variation by analyzing >300,000 de novo mutations from whole-genome trio sequencing and high-resolution nucleosome maps in human. We found that de novo mutation rates are elevated around strong, translationally stable nucleosomes, a previously under-appreciated aspect. We confirmed this observation having controlled for local sequence context and other potential confounding factors. Analysis of the underlying mutational processes suggests that the increased mutation rates around strong nucleosomes are shaped by a combination of low-fidelity replication, frequent DNA damage and insufficient/error-prone repair in these regions. Interestingly, strong nucleosomes are preferentially located in young SINE/LINE elements, implying frequent nucleosome re-positioning (i.e. shifting of dyad position) and their contribution to hypermutation at new retrotransposons during evolution. These findings provide novel insights into how chromatin organization affects germline mutation rates and have important implications in human genetics and genome evolution." @default.
• W2904253190 created "2018-12-22" @default.
• W2904253190 creator A5020382415 @default.
• W2904253190 creator A5043234753 @default.
• W2904253190 date "2018-12-13" @default.
• W2904253190 modified "2023-09-23" @default.
• W2904253190 title "Nucleosome positioning stability is a significant modulator of germline mutation rate variation across the human genome" @default.
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• W2904253190 doi "https://doi.org/10.1101/494914" @default.
• W2904253190 hasPublicationYear "2018" @default.
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