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- W2904256112 abstract "Recombinant measles viruses (MVs) have oncolytic activity against a variety of human cancers. However, their kinetics of spread within tumors has been unexplored. We established an intravital imaging system using the dorsal skin fold chamber, which allows for serial, non-invasive imaging of tumor cells and replication of a fusogenic and a hypofusogenic MV. Hypofusogenic virus-infected cells were detected at the earliest 3 days post-infection (dpi), with peak infection around 6 dpi. In contrast, the fusogenic virus replicated faster: infected cells were detectable 1 dpi and cells were killed quickly. Infection foci were significantly larger with the fusogenic virus. Both viruses formed syncytia. The spatial relationships between cells have a major influence on the outcome of therapy with oncolytic viruses." @default.
- W2904256112 created "2018-12-22" @default.
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- W2904256112 date "2019-03-01" @default.
- W2904256112 modified "2023-09-25" @default.
- W2904256112 title "In Vivo Imaging of Oncolytic Measles Virus Propagation with Single-Cell Resolution" @default.
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- W2904256112 doi "https://doi.org/10.1016/j.omto.2018.12.007" @default.
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