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- W2904257007 abstract "Presenilin is the catalytic subunit of γ-secretase, a four-component intramembrane protease responsible for the generation of β-amyloid (Aβ) peptides. Over 200 Alzheimer's disease-related mutations have been identified in presenilin 1 (PS1) and PS2. Here, we report that Bax-inhibitor 1 (BI1), an evolutionarily conserved transmembrane protein, stably associates with PS1. BI1 specifically interacts with PS1 in isolation, but not with PS1 in the context of an assembled γ-secretase. The PS1-BI1 complex exhibits no apparent proteolytic activity, as judged by the inability to produce Aβ40 and Aβ42 from the substrate APP-C99. At an equimolar concentration, BI1 has no impact on the proteolytic activity of γ-secretase; at a 200-fold molar excess, BI1 reduces γ-secretase activity nearly by half. Our biochemical study identified BI1 as a PS1-interacting protein, suggesting additional functions of PS1 beyond its involvement in γ-secretase." @default.
- W2904257007 created "2018-12-22" @default.
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- W2904257007 creator A5091493201 @default.
- W2904257007 date "2018-12-17" @default.
- W2904257007 modified "2023-10-18" @default.
- W2904257007 title "Bax inhibitor 1 is a γ-secretase–independent presenilin-binding protein" @default.
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- W2904257007 doi "https://doi.org/10.1073/pnas.1810870116" @default.
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