FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904258680> ?p ?o ?g. }

• W2904258680 abstract "TCSs help bacteria adapt to environmental stresses by altering gene expression. However, the roles and corresponding regulatory mechanisms of most TCSs in the Streptomyces model strain S. coelicolor are unknown. We investigated the previously uncharacterized MacRS TCS and identified the core DNA recognition sequence, two seven-nucleotide inverted repeats, for the DNA-binding protein MacR. We further found that MacR directly controls a group of membrane proteins, including MmpA-C, which are novel morphogenic factors that delay formation of aerial mycelium. We also discovered that these membrane proteins interact with one another and that other Streptomyces species have conserved MacRS homologs. Our findings suggest a conserved role for MacRS in morphogenesis and/or other membrane-associated activities. Additionally, our study showed that MacRS impacts, albeit indirectly, the production of the signature metabolite actinorhodin, further suggesting that MacRS and its homologs function as novel pleiotropic regulatory systems in Streptomyces ." @default.
• W2904258680 created "2018-12-22" @default.
• W2904258680 creator A5001577023 @default.
• W2904258680 creator A5013412416 @default.
• W2904258680 creator A5036697078 @default.
• W2904258680 creator A5047908354 @default.
• W2904258680 creator A5059257819 @default.
• W2904258680 creator A5071705008 @default.
• W2904258680 creator A5081023811 @default.
• W2904258680 creator A5083272185 @default.
• W2904258680 creator A5087592842 @default.
• W2904258680 creator A5087622468 @default.
• W2904258680 date "2019-02-15" @default.
• W2904258680 modified "2023-10-01" @default.
• W2904258680 title "Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in <i>Streptomyces coelicolor</i>" @default.
• W2904258680 cites W1481209183 @default.
• W2904258680 cites W1486239164 @default.
• W2904258680 cites W1522658170 @default.
• W2904258680 cites W1603944953 @default.
• W2904258680 cites W1884607886 @default.
• W2904258680 cites W1920241157 @default.
• W2904258680 cites W1954652720 @default.
• W2904258680 cites W1973493961 @default.
• W2904258680 cites W1975414190 @default.
• W2904258680 cites W1985029525 @default.
• W2904258680 cites W2001872144 @default.
• W2904258680 cites W2005315211 @default.
• W2904258680 cites W2012152224 @default.
• W2904258680 cites W2012960603 @default.
• W2904258680 cites W2017478893 @default.
• W2904258680 cites W2019350054 @default.
• W2904258680 cites W2023950913 @default.
• W2904258680 cites W2026435317 @default.
• W2904258680 cites W2031175574 @default.
• W2904258680 cites W2035133853 @default.
• W2904258680 cites W2040694642 @default.
• W2904258680 cites W2047670590 @default.
• W2904258680 cites W2056240004 @default.
• W2904258680 cites W2061131070 @default.
• W2904258680 cites W2061588341 @default.
• W2904258680 cites W2065018402 @default.
• W2904258680 cites W2077134205 @default.
• W2904258680 cites W2086506761 @default.
• W2904258680 cites W2096792637 @default.
• W2904258680 cites W2097107759 @default.
• W2904258680 cites W2106533616 @default.
• W2904258680 cites W2121080914 @default.
• W2904258680 cites W2124445891 @default.
• W2904258680 cites W2128170749 @default.
• W2904258680 cites W2130531083 @default.
• W2904258680 cites W2133290304 @default.
• W2904258680 cites W2136059909 @default.
• W2904258680 cites W2137076741 @default.
• W2904258680 cites W2148562498 @default.
• W2904258680 cites W2149248785 @default.
• W2904258680 cites W2153584471 @default.
• W2904258680 cites W2158215331 @default.
• W2904258680 cites W2161716412 @default.
• W2904258680 cites W2171164225 @default.
• W2904258680 cites W2442908178 @default.
• W2904258680 cites W2571094804 @default.
• W2904258680 cites W2621620920 @default.
• W2904258680 cites W2751226973 @default.
• W2904258680 cites W2762125782 @default.
• W2904258680 doi "https://doi.org/10.1128/aem.02178-18" @default.
• W2904258680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6365819" @default.
• W2904258680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30530707" @default.
• W2904258680 hasPublicationYear "2019" @default.
• W2904258680 type Work @default.
• W2904258680 sameAs 2904258680 @default.
• W2904258680 citedByCount "21" @default.
• W2904258680 countsByYear W29042586802019 @default.
• W2904258680 countsByYear W29042586802020 @default.
• W2904258680 countsByYear W29042586802021 @default.
• W2904258680 countsByYear W29042586802022 @default.
• W2904258680 countsByYear W29042586802023 @default.
• W2904258680 crossrefType "journal-article" @default.
• W2904258680 hasAuthorship W2904258680A5001577023 @default.
• W2904258680 hasAuthorship W2904258680A5013412416 @default.
• W2904258680 hasAuthorship W2904258680A5036697078 @default.
• W2904258680 hasAuthorship W2904258680A5047908354 @default.
• W2904258680 hasAuthorship W2904258680A5059257819 @default.
• W2904258680 hasAuthorship W2904258680A5071705008 @default.
• W2904258680 hasAuthorship W2904258680A5081023811 @default.
• W2904258680 hasAuthorship W2904258680A5083272185 @default.
• W2904258680 hasAuthorship W2904258680A5087592842 @default.
• W2904258680 hasAuthorship W2904258680A5087622468 @default.
• W2904258680 hasBestOaLocation W29042586801 @default.
• W2904258680 hasConcept C104317684 @default.
• W2904258680 hasConcept C14036430 @default.
• W2904258680 hasConcept C143065580 @default.
• W2904258680 hasConcept C165864922 @default.
• W2904258680 hasConcept C2776668381 @default.
• W2904258680 hasConcept C2779920670 @default.
• W2904258680 hasConcept C2780681812 @default.
• W2904258680 hasConcept C33498276 @default.
• W2904258680 hasConcept C523546767 @default.
• W2904258680 hasConcept C54355233 @default.
• W2904258680 hasConcept C86803240 @default.
• W2904258680 hasConcept C95444343 @default.

• next