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• W2904270746 abstract "Accumulation of visceral adiposity is directly linked to the morbidity of obesity, while subcutaneous body fat is considered more benign. We have identified an unexpected role for B cell lymphoma 6 (BCL6), a critical regulator of immunity, in the developmental expansion of subcutaneous adipose tissue. In adipocyte-specific knockout mice (Bcl6AKO), we found that Bcl6 deletion results in strikingly increased inguinal, but not perigonadal, adipocyte size and tissue mass in addition to marked insulin sensitivity. Genome-wide RNA expression and DNA binding analyses revealed that BCL6 controls gene networks involved in cell growth and fatty acid biosynthesis. Using deuterium label incorporation and comprehensive adipokine and lipid profiling, we discovered that ablation of adipocyte Bcl6 enhances subcutaneous adipocyte lipogenesis, increases levels of adiponectin and fatty acid esters of hydroxy fatty acids (FAHFAs), and prevents steatosis. Thus, our studies identify BCL6 as a negative regulator of subcutaneous adipose tissue expansion and metabolic health." @default.
• W2904270746 created "2018-12-22" @default.
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• W2904270746 date "2018-12-01" @default.
• W2904270746 modified "2023-10-17" @default.
• W2904270746 title "Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity" @default.
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• W2904270746 doi "https://doi.org/10.1016/j.celrep.2018.11.074" @default.
• W2904270746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6377366" @default.
• W2904270746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30566857" @default.
• W2904270746 hasPublicationYear "2018" @default.
• W2904270746 type Work @default.
• W2904270746 sameAs 2904270746 @default.

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