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- W2904272106 abstract "Abstract Runx2 plays an essential role in embryonic disc tissue development in mice. However, the role of runt‐related transcription factor 2 (Runx2) in postnatal disc tissue growth and development has not been defined. In the present studies, we generated Runx2 conditional knockout (KO) mice ( Runx2 Agc1ER ), in which Runx2 was deleted in Aggrecan‐expressing cells in disc tissue at postnatal 2‐weeks of age. We then analyzed changes in disc tissue growth and development using histology and immunohistochemical methods in 3‐month‐old mice. We found that large vacuolated notochordal cells were accumulated in the nucleus pulposus (NP) in Runx2 KO mice. The growth plate cartilage tissue in the disc was thicker in Runx2 KO mice. We also found a significant upregulation of Indian hedgehog (Ihh) expression in the cells in NP cells and in annulus fibrosus cells of Runx2 KO mice. These results demonstrated that Runx2 may play an important role in postnatal disc tissue development through interacting with Ihh signaling." @default.
- W2904272106 created "2018-12-22" @default.
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- W2904272106 date "2018-10-20" @default.
- W2904272106 modified "2023-10-14" @default.
- W2904272106 title "Runx2 is required for postnatal intervertebral disc tissue growth and development" @default.
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- W2904272106 doi "https://doi.org/10.1002/jcp.27410" @default.
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