FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904276522> ?p ?o ?g. }

• W2904276522 endingPage "11000" @default.
• W2904276522 startingPage "10990" @default.
• W2904276522 abstract "Abstract Oxidized low‐density lipoprotein (Ox‐LDL)‐induced endothelial cell injury plays a crucial role in the pathogenesis of atherosclerosis (AS). Plasma galectin‐3 (Gal‐3) is elevated inside and drives diverse systemic inflammatory disorders, including cardiovascular diseases. However, the exact role of Gal‐3 in ox‐LDL‐mediated endothelial injury remains unclear. This study explores the effects of Gal‐3 on ox‐LDL‐induced endothelial dysfunction and the underlying molecular mechanisms. In this study, Gal‐3, integrin β1, and GTP‐RhoA in the blood and plaques of AS patients were examined by ELISA and western blot respectively. Their levels were found to be obviously upregulated compared with non‐AS control group. CCK8 assay and flow cytometry analysis showed that Gal‐3 significantly decreased cell viability and promoted apoptosis in ox‐LDL‐treated human umbilical vascular endothelial cells (HUVECs). The upregulation of integrinβ1, GTP‐RhoA, p‐JNK, p‐p65, p‐IKKα, and p‐IKKβ induced by ox‐LDL was further enhanced by treatment with Gal‐3. Pretreatment with Gal‐3 increased expression of inflammatory factors (interleukin [IL]‐6, IL‐8, and IL‐1β), chemokines(CXCL‐1 and CCL‐2) and adhesion molecules (VCAM‐1 and ICAM‐1). Furthermore, the promotional effects of Gal‐3 on NF‐κB activation and inflammatory factors in ox‐LDL‐treated HUVECs were reversed by the treatments with integrinβ1‐siRNA or the JNK inhibitor. We also found that integrinβ1‐siRNA decreased the protein expression of GTP‐RhoA and p‐JNK, while RhoA inhibitor partially reduced the upregulated expression of p‐JNK induced by Gal‐3. In conclusion, our finding suggests that Gal‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation." @default.
• W2904276522 created "2018-12-22" @default.
• W2904276522 creator A5027006186 @default.
• W2904276522 creator A5036656079 @default.
• W2904276522 creator A5039723954 @default.
• W2904276522 creator A5040858214 @default.
• W2904276522 creator A5042316643 @default.
• W2904276522 creator A5045955789 @default.
• W2904276522 creator A5052836808 @default.
• W2904276522 creator A5063880073 @default.
• W2904276522 creator A5073846185 @default.
• W2904276522 creator A5074911294 @default.
• W2904276522 creator A5088557749 @default.
• W2904276522 date "2018-12-10" @default.
• W2904276522 modified "2023-10-06" @default.
• W2904276522 title "Galectin‐3 exacerbates ox‐LDL‐mediated endothelial injury by inducing inflammation via integrin β1‐RhoA‐JNK signaling activation" @default.
• W2904276522 cites W1618619778 @default.
• W2904276522 cites W1949072443 @default.
• W2904276522 cites W1975951092 @default.
• W2904276522 cites W2014097940 @default.
• W2904276522 cites W2022453849 @default.
• W2904276522 cites W2094188666 @default.
• W2904276522 cites W2101541453 @default.
• W2904276522 cites W2109257372 @default.
• W2904276522 cites W2112707577 @default.
• W2904276522 cites W2116999983 @default.
• W2904276522 cites W2123322428 @default.
• W2904276522 cites W2135164569 @default.
• W2904276522 cites W2142633227 @default.
• W2904276522 cites W2149322454 @default.
• W2904276522 cites W2158020124 @default.
• W2904276522 cites W2161321429 @default.
• W2904276522 cites W2172281761 @default.
• W2904276522 cites W2249646224 @default.
• W2904276522 cites W2403123368 @default.
• W2904276522 cites W2407777544 @default.
• W2904276522 cites W2467077417 @default.
• W2904276522 cites W2500965837 @default.
• W2904276522 cites W2520268531 @default.
• W2904276522 cites W2560409429 @default.
• W2904276522 cites W2574642432 @default.
• W2904276522 cites W2591837733 @default.
• W2904276522 cites W2604897934 @default.
• W2904276522 cites W2617542341 @default.
• W2904276522 cites W2640456656 @default.
• W2904276522 cites W2753188950 @default.
• W2904276522 cites W2763004693 @default.
• W2904276522 cites W2772075695 @default.
• W2904276522 cites W2774817182 @default.
• W2904276522 cites W2791286875 @default.
• W2904276522 cites W2793749910 @default.
• W2904276522 cites W2793798288 @default.
• W2904276522 cites W2795636064 @default.
• W2904276522 doi "https://doi.org/10.1002/jcp.27910" @default.
• W2904276522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6590151" @default.
• W2904276522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30536538" @default.
• W2904276522 hasPublicationYear "2018" @default.
• W2904276522 type Work @default.
• W2904276522 sameAs 2904276522 @default.
• W2904276522 citedByCount "29" @default.
• W2904276522 countsByYear W29042765222019 @default.
• W2904276522 countsByYear W29042765222020 @default.
• W2904276522 countsByYear W29042765222021 @default.
• W2904276522 countsByYear W29042765222022 @default.
• W2904276522 countsByYear W29042765222023 @default.
• W2904276522 crossrefType "journal-article" @default.
• W2904276522 hasAuthorship W2904276522A5027006186 @default.
• W2904276522 hasAuthorship W2904276522A5036656079 @default.
• W2904276522 hasAuthorship W2904276522A5039723954 @default.
• W2904276522 hasAuthorship W2904276522A5040858214 @default.
• W2904276522 hasAuthorship W2904276522A5042316643 @default.
• W2904276522 hasAuthorship W2904276522A5045955789 @default.
• W2904276522 hasAuthorship W2904276522A5052836808 @default.
• W2904276522 hasAuthorship W2904276522A5063880073 @default.
• W2904276522 hasAuthorship W2904276522A5073846185 @default.
• W2904276522 hasAuthorship W2904276522A5074911294 @default.
• W2904276522 hasAuthorship W2904276522A5088557749 @default.
• W2904276522 hasBestOaLocation W29042765221 @default.
• W2904276522 hasConcept C104317684 @default.
• W2904276522 hasConcept C127561419 @default.
• W2904276522 hasConcept C13373296 @default.
• W2904276522 hasConcept C1491633281 @default.
• W2904276522 hasConcept C153911025 @default.
• W2904276522 hasConcept C16224149 @default.
• W2904276522 hasConcept C185592680 @default.
• W2904276522 hasConcept C195687474 @default.
• W2904276522 hasConcept C203014093 @default.
• W2904276522 hasConcept C2776914184 @default.
• W2904276522 hasConcept C2777093181 @default.
• W2904276522 hasConcept C502942594 @default.
• W2904276522 hasConcept C55493867 @default.
• W2904276522 hasConcept C62478195 @default.
• W2904276522 hasConcept C86803240 @default.
• W2904276522 hasConcept C95444343 @default.
• W2904276522 hasConceptScore W2904276522C104317684 @default.
• W2904276522 hasConceptScore W2904276522C127561419 @default.
• W2904276522 hasConceptScore W2904276522C13373296 @default.
• W2904276522 hasConceptScore W2904276522C1491633281 @default.

• next