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• W2904279187 abstract "Domain structure of paracetamol -- popular antipyretic analgesic -- was investigated by infrared (IR) spectroscopy using synchrotron radiation. Absorbance and retardance maps reveal molecular orientation inside the micro-domains of the paracetamol form II which has a better water solubility and compressibility compared to the commercially used forms I. The developed method of analysis representing orientation of optical slow(fast)-axis is compared with azimuthal orientation of the absorbance at several specific IR bands using vector maps. High brightness of synchrotron radiation and hyper-spectral mapping of structural domains in paracetamol clearly reveals the domain boundaries and can potentially be used to observe emph{in situ} intra-phase transformations of paracetamol forms-I, II, III and melting, which are important for making medical tablets and powders by an industrial process." @default.
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• W2904279187 date "2019-04-01" @default.
• W2904279187 modified "2023-10-17" @default.
• W2904279187 title "Paracetamol micro-structure analysis by optical mapping" @default.
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• W2904279187 doi "https://doi.org/10.1016/j.apsusc.2018.12.121" @default.
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