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• W2904280031 startingPage "1685" @default.
• W2904280031 abstract "Folding can bestow macromolecules with various properties, as evident from nature’s proteins. Until now complex folded molecules are the product either of evolution or of an elaborate process of design and synthesis. We now show that molecules that fold in a well-defined architecture of substantial complexity can emerge autonomously and selectively from a simple precursor. Specifically, we have identified a self-synthesizing macrocyclic foldamer with a complex and unprecedented secondary and tertiary structure that constructs itself highly selectively from 15 identical peptide-nucleobase subunits, using a dynamic combinatorial chemistry approach. Folding of the structure drives its synthesis in 95% yield from a mixture of interconverting molecules of different ring sizes in a one-step process. Single-crystal X-ray crystallography and NMR reveal a folding pattern based on an intricate network of noncovalent interactions involving residues spaced apart widely in the linear sequence. These results establish dynamic combinatorial chemistry as a powerful approach to developing synthetic molecules with folding motifs of a complexity that goes well beyond that accessible with current design approaches. The fact that such molecules can form autonomously implies that they may have played a role in the origin of life at earlier stages than previously thought possible." @default.
• W2904280031 created "2018-12-22" @default.
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• W2904280031 date "2018-12-18" @default.
• W2904280031 modified "2023-10-17" @default.
• W2904280031 title "Complex Molecules That Fold Like Proteins Can Emerge Spontaneously" @default.
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• W2904280031 doi "https://doi.org/10.1021/jacs.8b11698" @default.
• W2904280031 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356852" @default.
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• W2904280031 hasPublicationYear "2018" @default.
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