Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904282317> ?p ?o ?g. }
- W2904282317 endingPage "e0006979" @default.
- W2904282317 startingPage "e0006979" @default.
- W2904282317 abstract "Background In previous studies, we suggested that Acanthamoeba is a new aero-allergen and that patients who showed positive results for the skin-prick test response to Acanthamoeba cross-reacted with several pollen allergens. Additionally, patients with common antibodies reacted to the 13–15 kDa Acanthamoeba unknown allergen. Objective We examined whether profilin of Acanthamoeba is a human airway allergic agent because of its molecular weight. Methods We expressed recombinant Ac-PF (rAc-PF) protein using an Escherichia coli expression system and evaluated whether Ac-PF is an airway allergic agent using an allergic airway inflammation animal model. Results Airway hyperresponsiveness was increased in rAc-PF-inoculated mice. The number of eosinophils and levels of Th2 cytokines, interleukin (IL)-4, IL-5, and IL-13 were increased in the bronchial alveolar lavage fluid of rAc-PF-treated mice. The lungs of the rAc-PF-treated mice group showed enhanced mucin production and metaplasia of lung epithelial cells and goblet cells. Conclusion In this study, we demonstrated that rAc-PF may be an allergen in Acanthamoeba, but further studies needed to identify the mechanisms of allergenic reactions induced by Ac-PF." @default.
- W2904282317 created "2018-12-22" @default.
- W2904282317 creator A5039987199 @default.
- W2904282317 creator A5044335175 @default.
- W2904282317 creator A5048448756 @default.
- W2904282317 creator A5075272515 @default.
- W2904282317 creator A5077539926 @default.
- W2904282317 creator A5084209005 @default.
- W2904282317 creator A5089384653 @default.
- W2904282317 date "2018-12-17" @default.
- W2904282317 modified "2023-09-27" @default.
- W2904282317 title "Acanthamoeba profilin elicits allergic airway inflammation in mice" @default.
- W2904282317 cites W1508622928 @default.
- W2904282317 cites W1668142298 @default.
- W2904282317 cites W1964236906 @default.
- W2904282317 cites W1965072920 @default.
- W2904282317 cites W1969255709 @default.
- W2904282317 cites W1970672159 @default.
- W2904282317 cites W1986190391 @default.
- W2904282317 cites W1995158194 @default.
- W2904282317 cites W2003341565 @default.
- W2904282317 cites W2006620904 @default.
- W2904282317 cites W2009987865 @default.
- W2904282317 cites W2012579360 @default.
- W2904282317 cites W2016202715 @default.
- W2904282317 cites W2018340625 @default.
- W2904282317 cites W2020037351 @default.
- W2904282317 cites W2023037761 @default.
- W2904282317 cites W2026028987 @default.
- W2904282317 cites W2032611208 @default.
- W2904282317 cites W2034660356 @default.
- W2904282317 cites W2036260707 @default.
- W2904282317 cites W2047831969 @default.
- W2904282317 cites W2051548814 @default.
- W2904282317 cites W2055057077 @default.
- W2904282317 cites W2059069811 @default.
- W2904282317 cites W2084021913 @default.
- W2904282317 cites W2086122467 @default.
- W2904282317 cites W2089339054 @default.
- W2904282317 cites W2098231476 @default.
- W2904282317 cites W2104289972 @default.
- W2904282317 cites W2116719441 @default.
- W2904282317 cites W2129378901 @default.
- W2904282317 cites W2132377598 @default.
- W2904282317 cites W2137245547 @default.
- W2904282317 cites W2144509220 @default.
- W2904282317 cites W2150200156 @default.
- W2904282317 cites W2154719091 @default.
- W2904282317 cites W2168522749 @default.
- W2904282317 cites W2299264647 @default.
- W2904282317 cites W2582576746 @default.
- W2904282317 cites W4298376011 @default.
- W2904282317 doi "https://doi.org/10.1371/journal.pntd.0006979" @default.
- W2904282317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6312355" @default.
- W2904282317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30557322" @default.
- W2904282317 hasPublicationYear "2018" @default.
- W2904282317 type Work @default.
- W2904282317 sameAs 2904282317 @default.
- W2904282317 citedByCount "5" @default.
- W2904282317 countsByYear W29042823172021 @default.
- W2904282317 countsByYear W29042823172022 @default.
- W2904282317 countsByYear W29042823172023 @default.
- W2904282317 crossrefType "journal-article" @default.
- W2904282317 hasAuthorship W2904282317A5039987199 @default.
- W2904282317 hasAuthorship W2904282317A5044335175 @default.
- W2904282317 hasAuthorship W2904282317A5048448756 @default.
- W2904282317 hasAuthorship W2904282317A5075272515 @default.
- W2904282317 hasAuthorship W2904282317A5077539926 @default.
- W2904282317 hasAuthorship W2904282317A5084209005 @default.
- W2904282317 hasAuthorship W2904282317A5089384653 @default.
- W2904282317 hasBestOaLocation W29042823171 @default.
- W2904282317 hasConcept C136449434 @default.
- W2904282317 hasConcept C142669718 @default.
- W2904282317 hasConcept C142724271 @default.
- W2904282317 hasConcept C1491633281 @default.
- W2904282317 hasConcept C179264091 @default.
- W2904282317 hasConcept C203014093 @default.
- W2904282317 hasConcept C203253989 @default.
- W2904282317 hasConcept C207480886 @default.
- W2904282317 hasConcept C2775941134 @default.
- W2904282317 hasConcept C2776914184 @default.
- W2904282317 hasConcept C2777438239 @default.
- W2904282317 hasConcept C2778868110 @default.
- W2904282317 hasConcept C2779675166 @default.
- W2904282317 hasConcept C2780510475 @default.
- W2904282317 hasConcept C2993400109 @default.
- W2904282317 hasConcept C529295009 @default.
- W2904282317 hasConcept C54355233 @default.
- W2904282317 hasConcept C71924100 @default.
- W2904282317 hasConcept C86803240 @default.
- W2904282317 hasConcept C8891405 @default.
- W2904282317 hasConcept C89423630 @default.
- W2904282317 hasConceptScore W2904282317C136449434 @default.
- W2904282317 hasConceptScore W2904282317C142669718 @default.
- W2904282317 hasConceptScore W2904282317C142724271 @default.
- W2904282317 hasConceptScore W2904282317C1491633281 @default.
- W2904282317 hasConceptScore W2904282317C179264091 @default.
- W2904282317 hasConceptScore W2904282317C203014093 @default.