Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904289013> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2904289013 abstract "The need for an alternative means of managing renal toxicity has become necessary instead of kidney transplant. This study investigated the effect of aqueous extract of Ocimum gratissimum (AEOG) on acetaminophen (ACE) induced renal toxicity. Twenty-five male Wistar rats were assigned into five groups (1, 2, 3, 4, and 5) with five rats in each group. Group 1 served as the normal control and received normal saline as placebo. Group 2 served as the negative control and received 500 mg/kg of ACE orally for 21 days. Groups 3, 4 and 5 served as the treatment groups and received 100, 200 and 400 mg/kg AEOG in addition to 500 mg/kg ACE orally for 21 days. The animals were sacrificed on the 22nd day. Blood was collected for the biochemical analysis (serum creatinine, urea and electrolytes). The kidney was harvested, rinsed in 1% KCl and preserved in 10% formaldehyde solution for the histological examination. The phytochemical analysis indicates the presence of tannins, flavonoids, saponin, alkaloids, phenols, phlobatamin, anthraquinone, terpernoids, steroids, cardiac glycosides and absence of cardenolides and chalcones. Biochemical analysis showed significant increase in creatinine and urea levels in the negative control groups when compared with the normal control while there was no significant decrease in both creatinine and urea in the treatment groups when compared with the negative control. There was no significant difference (p>0.05) in the serum electrolytes (Na+, K+, Cl-, and HCO3-). The histological examination showed mild and moderate healing of the renal tissues in the treatment groups when compared with the negative control group which showed severely damaged renal tissues. Based on the aforementioned observations, it was concluded that AEOG possessed ameliorative effect in ACE induced renal toxicity.Key words: Renal toxicity, acetaminophen, Occimum gratissimium, rats, electrolytes." @default.
- W2904289013 created "2018-12-22" @default.
- W2904289013 creator A5012121880 @default.
- W2904289013 creator A5029924417 @default.
- W2904289013 creator A5056820712 @default.
- W2904289013 creator A5060522361 @default.
- W2904289013 creator A5063308877 @default.
- W2904289013 creator A5076701682 @default.
- W2904289013 date "2018-11-25" @default.
- W2904289013 modified "2023-10-01" @default.
- W2904289013 title "Effect of aqueous extract of Ocimum gratissimum on acetaminophen induced renal toxicity in male wistar rats" @default.
- W2904289013 cites W1983585817 @default.
- W2904289013 cites W1987965490 @default.
- W2904289013 cites W2016750201 @default.
- W2904289013 cites W2055326197 @default.
- W2904289013 cites W2150124540 @default.
- W2904289013 cites W2590394666 @default.
- W2904289013 cites W2764008990 @default.
- W2904289013 doi "https://doi.org/10.5897/jmpr2018.6678" @default.
- W2904289013 hasPublicationYear "2018" @default.
- W2904289013 type Work @default.
- W2904289013 sameAs 2904289013 @default.
- W2904289013 citedByCount "0" @default.
- W2904289013 crossrefType "journal-article" @default.
- W2904289013 hasAuthorship W2904289013A5012121880 @default.
- W2904289013 hasAuthorship W2904289013A5029924417 @default.
- W2904289013 hasAuthorship W2904289013A5056820712 @default.
- W2904289013 hasAuthorship W2904289013A5060522361 @default.
- W2904289013 hasAuthorship W2904289013A5063308877 @default.
- W2904289013 hasAuthorship W2904289013A5076701682 @default.
- W2904289013 hasBestOaLocation W29042890131 @default.
- W2904289013 hasConcept C126189478 @default.
- W2904289013 hasConcept C126322002 @default.
- W2904289013 hasConcept C185592680 @default.
- W2904289013 hasConcept C195475562 @default.
- W2904289013 hasConcept C2777056448 @default.
- W2904289013 hasConcept C2780091579 @default.
- W2904289013 hasConcept C2780306776 @default.
- W2904289013 hasConcept C2780365088 @default.
- W2904289013 hasConcept C2780962921 @default.
- W2904289013 hasConcept C29730261 @default.
- W2904289013 hasConcept C55493867 @default.
- W2904289013 hasConcept C556039675 @default.
- W2904289013 hasConcept C71924100 @default.
- W2904289013 hasConcept C98274493 @default.
- W2904289013 hasConceptScore W2904289013C126189478 @default.
- W2904289013 hasConceptScore W2904289013C126322002 @default.
- W2904289013 hasConceptScore W2904289013C185592680 @default.
- W2904289013 hasConceptScore W2904289013C195475562 @default.
- W2904289013 hasConceptScore W2904289013C2777056448 @default.
- W2904289013 hasConceptScore W2904289013C2780091579 @default.
- W2904289013 hasConceptScore W2904289013C2780306776 @default.
- W2904289013 hasConceptScore W2904289013C2780365088 @default.
- W2904289013 hasConceptScore W2904289013C2780962921 @default.
- W2904289013 hasConceptScore W2904289013C29730261 @default.
- W2904289013 hasConceptScore W2904289013C55493867 @default.
- W2904289013 hasConceptScore W2904289013C556039675 @default.
- W2904289013 hasConceptScore W2904289013C71924100 @default.
- W2904289013 hasConceptScore W2904289013C98274493 @default.
- W2904289013 hasLocation W29042890131 @default.
- W2904289013 hasOpenAccess W2904289013 @default.
- W2904289013 hasPrimaryLocation W29042890131 @default.
- W2904289013 hasRelatedWork W2096408355 @default.
- W2904289013 hasRelatedWork W2145443883 @default.
- W2904289013 hasRelatedWork W2150063442 @default.
- W2904289013 hasRelatedWork W2461833267 @default.
- W2904289013 hasRelatedWork W2496501284 @default.
- W2904289013 hasRelatedWork W2625241710 @default.
- W2904289013 hasRelatedWork W2725353566 @default.
- W2904289013 hasRelatedWork W2782072462 @default.
- W2904289013 hasRelatedWork W2889505134 @default.
- W2904289013 hasRelatedWork W2891046917 @default.
- W2904289013 hasRelatedWork W2904775798 @default.
- W2904289013 hasRelatedWork W2907600667 @default.
- W2904289013 hasRelatedWork W2997363998 @default.
- W2904289013 hasRelatedWork W3046825417 @default.
- W2904289013 hasRelatedWork W3093733787 @default.
- W2904289013 hasRelatedWork W42415577 @default.
- W2904289013 hasRelatedWork W2185621742 @default.
- W2904289013 hasRelatedWork W3164097794 @default.
- W2904289013 hasRelatedWork W3195552622 @default.
- W2904289013 hasRelatedWork W896509201 @default.
- W2904289013 isParatext "false" @default.
- W2904289013 isRetracted "false" @default.
- W2904289013 magId "2904289013" @default.
- W2904289013 workType "article" @default.