FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904290055> ?p ?o ?g. }

• W2904290055 endingPage "458" @default.
• W2904290055 startingPage "450" @default.
• W2904290055 abstract "Abstract We examined the potential contributions of oxidative stress and thromboxane A 2 (TXA 2 ) to the development of regional heterogeneity in hypertensive glomerular injury using stroke-prone spontaneously hypertensive rats (SHRSP), an animal model of human essential hypertension. We also examined the effect of antioxidant treatment on the regional expression of thromboxane synthase (TXAS) mRNA using a microdissection method. Increases in the glomerular expression of TXAS mRNA were observed in the SHRSP at 15 weeks of age compared with those in the age-matched normotensive control Wistar–Kyoto (WKY) rats: 2.4-fold and 3.1-fold in the superficial and juxtamedullary glomeruli, respectively ( P < 0.05). The heme oxygenase-1 mRNA expression was markedly increased (greater than eightfold, P < 0.05) in both the superficial and juxtamedullary glomeruli in the SHRSP compared with the expression in the WKY rats. In contrast to our expectations, the treatment of SHRSP with tempol (a superoxide dismutase mimetic) significantly ( P < 0.05) increased the TXAS mRNA expression in the superficial glomeruli and did not improve the histological injury or albuminuria, which were both aggravated. Moreover, ozagrel (a TXAS inhibitor) had a suppressive effect on the TXAS mRNA expression and significantly ( P < 0.05) improved the histological injury. These results indicated that although TXA 2 and oxidative stress are linked to each other, TXA 2 rather than oxidative stress may be a better therapeutic target to improve hypertensive glomerular injury." @default.
• W2904290055 created "2018-12-22" @default.
• W2904290055 creator A5007681475 @default.
• W2904290055 creator A5064936836 @default.
• W2904290055 creator A5074132480 @default.
• W2904290055 creator A5083014712 @default.
• W2904290055 creator A5090362877 @default.
• W2904290055 date "2018-12-13" @default.
• W2904290055 modified "2023-10-13" @default.
• W2904290055 title "Diverse associations between oxidative stress and thromboxane A2 in hypertensive glomerular injury" @default.
• W2904290055 cites W1970331846 @default.
• W2904290055 cites W1970517947 @default.
• W2904290055 cites W1970709580 @default.
• W2904290055 cites W1976239472 @default.
• W2904290055 cites W1987411653 @default.
• W2904290055 cites W2010395737 @default.
• W2904290055 cites W2014193928 @default.
• W2904290055 cites W2020532593 @default.
• W2904290055 cites W2021915764 @default.
• W2904290055 cites W2021937385 @default.
• W2904290055 cites W2029733337 @default.
• W2904290055 cites W2031540167 @default.
• W2904290055 cites W2034966887 @default.
• W2904290055 cites W2036811146 @default.
• W2904290055 cites W2043757888 @default.
• W2904290055 cites W2047446648 @default.
• W2904290055 cites W2048449484 @default.
• W2904290055 cites W2053097440 @default.
• W2904290055 cites W2055939737 @default.
• W2904290055 cites W2058217708 @default.
• W2904290055 cites W2061965955 @default.
• W2904290055 cites W2062139715 @default.
• W2904290055 cites W2072869822 @default.
• W2904290055 cites W2080605484 @default.
• W2904290055 cites W2084032015 @default.
• W2904290055 cites W2107277218 @default.
• W2904290055 cites W2107687115 @default.
• W2904290055 cites W2109595776 @default.
• W2904290055 cites W2116548587 @default.
• W2904290055 cites W2117801955 @default.
• W2904290055 cites W2118226128 @default.
• W2904290055 cites W2139758813 @default.
• W2904290055 cites W2142660334 @default.
• W2904290055 cites W2159020799 @default.
• W2904290055 cites W2166758273 @default.
• W2904290055 cites W2166838509 @default.
• W2904290055 cites W2167040553 @default.
• W2904290055 cites W2225273165 @default.
• W2904290055 cites W2332836926 @default.
• W2904290055 cites W2753449007 @default.
• W2904290055 doi "https://doi.org/10.1038/s41440-018-0162-x" @default.
• W2904290055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8075916" @default.
• W2904290055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30542084" @default.
• W2904290055 hasPublicationYear "2018" @default.
• W2904290055 type Work @default.
• W2904290055 sameAs 2904290055 @default.
• W2904290055 citedByCount "8" @default.
• W2904290055 countsByYear W29042900552019 @default.
• W2904290055 countsByYear W29042900552020 @default.
• W2904290055 countsByYear W29042900552021 @default.
• W2904290055 countsByYear W29042900552023 @default.
• W2904290055 crossrefType "journal-article" @default.
• W2904290055 hasAuthorship W2904290055A5007681475 @default.
• W2904290055 hasAuthorship W2904290055A5064936836 @default.
• W2904290055 hasAuthorship W2904290055A5074132480 @default.
• W2904290055 hasAuthorship W2904290055A5083014712 @default.
• W2904290055 hasAuthorship W2904290055A5090362877 @default.
• W2904290055 hasBestOaLocation W29042900551 @default.
• W2904290055 hasConcept C126322002 @default.
• W2904290055 hasConcept C134018914 @default.
• W2904290055 hasConcept C170493617 @default.
• W2904290055 hasConcept C173202427 @default.
• W2904290055 hasConcept C2775838275 @default.
• W2904290055 hasConcept C2776151105 @default.
• W2904290055 hasConcept C2776785769 @default.
• W2904290055 hasConcept C2778401633 @default.
• W2904290055 hasConcept C2781024287 @default.
• W2904290055 hasConcept C71924100 @default.
• W2904290055 hasConcept C89560881 @default.
• W2904290055 hasConceptScore W2904290055C126322002 @default.
• W2904290055 hasConceptScore W2904290055C134018914 @default.
• W2904290055 hasConceptScore W2904290055C170493617 @default.
• W2904290055 hasConceptScore W2904290055C173202427 @default.
• W2904290055 hasConceptScore W2904290055C2775838275 @default.
• W2904290055 hasConceptScore W2904290055C2776151105 @default.
• W2904290055 hasConceptScore W2904290055C2776785769 @default.
• W2904290055 hasConceptScore W2904290055C2778401633 @default.
• W2904290055 hasConceptScore W2904290055C2781024287 @default.
• W2904290055 hasConceptScore W2904290055C71924100 @default.
• W2904290055 hasConceptScore W2904290055C89560881 @default.
• W2904290055 hasIssue "4" @default.
• W2904290055 hasLocation W29042900551 @default.
• W2904290055 hasLocation W29042900552 @default.
• W2904290055 hasOpenAccess W2904290055 @default.
• W2904290055 hasPrimaryLocation W29042900551 @default.
• W2904290055 hasRelatedWork W1990447376 @default.
• W2904290055 hasRelatedWork W2014181690 @default.
• W2904290055 hasRelatedWork W2041257525 @default.

• next