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- W2904290465 endingPage "12266" @default.
- W2904290465 startingPage "12249" @default.
- W2904290465 abstract "Abstract Cardiac complications including arrhythmia and especially atrial fibrillation (AF) are common causes of death in β‐thalassemia patients. The main factor in the etiopathogenesis of these complications is iron overload, which results in increased oxidative stress. Although there is a known association between cardiac complications and iron overload in β‐thalassemia patients, there is no comprehensive review on AF and excessive iron with a focus on oxidative stress in these patients. The aim of this article was to review the different aspects of AF in β‐thalassemia patients with a focus on the prevention and treatment of AF by using iron chelators and/or anti‐oxidants. AF in β‐thalassemia patients is more common than in the general population. One of the most important causes of AF is cardiac iron overload and the harmful effects of increased oxidative stress. Iron‐induced AF can be reversed by using an intensive iron chelation regimen. Based on a few experimental studies, the combination of iron chelators with some anti‐oxidants, including NAC, vitamin C, and acetaminophen, can lead to improved cardiac protection. However, the effect of such combinations on cardiac arrhythmias should be further evaluated with animal and human studies." @default.
- W2904290465 created "2018-12-22" @default.
- W2904290465 creator A5009615283 @default.
- W2904290465 creator A5013584043 @default.
- W2904290465 creator A5015394492 @default.
- W2904290465 creator A5019227987 @default.
- W2904290465 creator A5031560022 @default.
- W2904290465 creator A5055763764 @default.
- W2904290465 creator A5077493249 @default.
- W2904290465 creator A5085465720 @default.
- W2904290465 date "2018-12-10" @default.
- W2904290465 modified "2023-09-23" @default.
- W2904290465 title "Atrial fibrillation in β‐thalassemia patients with a focus on the role of iron‐overload and oxidative stress: A review" @default.
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