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• W2904291625 abstract "PGC-1β is a transcriptional co-activator of nuclear receptors such as the estrogen receptor-related receptor (ERR). Transgenic overexpression of PGC-1β in mice increases energy expenditure and suppresses high-fat diet-induced obesity. In this study, we screened various food-derived and natural compounds using a reporter assay system to measure the transcriptional activity of PGC-1β. Soy-derived isoflavones, genistein and daidzein, and several resveratrols activated PGC-1β. Genistein, daidzein, and trans-oxyresveratrol activated ERR-responsive element-mediated reporter activity in the presence of PGC-1β. Stable overexpression of PGC-1β in C2C12 myoblasts increased the expression of medium-chain acyl-CoA dehydrogenase (MCAD), an important enzyme in fatty acid β-oxidation. Genistein and daidzein increased MCAD mRNA levels and mitochondrial content in PGC-1β-expressing C2C12 cells. These compounds activated ERR/PGC-1β complex-mediated gene expression, and our findings may be a practical foundation for developing functional foods targeting obesity." @default.
• W2904291625 created "2018-12-22" @default.
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• W2904291625 date "2019-03-01" @default.
• W2904291625 modified "2023-09-27" @default.
• W2904291625 title "Genistein, daidzein, and resveratrols stimulate PGC-1β-mediated gene expression" @default.
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• W2904291625 doi "https://doi.org/10.1016/j.bbrep.2018.11.009" @default.
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