Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904295959> ?p ?o ?g. }
- W2904295959 endingPage "333" @default.
- W2904295959 startingPage "322" @default.
- W2904295959 abstract "Our laboratories have been investigating synthetic analogues of marine alkaloid rigidins that possess promising anticancer activities. These analogues, based on the 7-deazahypoxanthine skeleton, are available in one- or two-step synthetic sequences and exert cytotoxicity by disrupting microtubule dynamics in cancer cells. In the present work we extended the available structure-activity relationship (SAR) data to N3- and N9-substituted derivatives. Although N3 substitution results in loss of activity, the N9-substituted compounds retain nanomolar antiproliferative activities and the anti-tubulin mode of action of the original unsubstituted compounds. Furthermore, our results also demonstrate that multidrug-resistance (MDR) proteins do not confer resistance to both N9-unsubstituted and -substituted compounds. It was found that sublines overexpressing ABCG2, ABCC1, and ABCB1 proteins are as responsive to the rigidin analogues as their parental cell lines. Thus, the study reported herein provides further impetus to investigate the rigidin-inspired 7-deazahypoxanthines as promising anticancer agents." @default.
- W2904295959 created "2018-12-22" @default.
- W2904295959 creator A5009000319 @default.
- W2904295959 creator A5013479056 @default.
- W2904295959 creator A5015296457 @default.
- W2904295959 creator A5027735851 @default.
- W2904295959 creator A5040489938 @default.
- W2904295959 creator A5041070542 @default.
- W2904295959 creator A5051258309 @default.
- W2904295959 creator A5053078484 @default.
- W2904295959 creator A5056602578 @default.
- W2904295959 creator A5058939223 @default.
- W2904295959 creator A5059795073 @default.
- W2904295959 creator A5060077054 @default.
- W2904295959 creator A5065954237 @default.
- W2904295959 creator A5069432364 @default.
- W2904295959 creator A5072815472 @default.
- W2904295959 creator A5084802244 @default.
- W2904295959 creator A5084829441 @default.
- W2904295959 date "2019-01-25" @default.
- W2904295959 modified "2023-09-27" @default.
- W2904295959 title "Microtubule‐Targeting 7‐Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug‐Resistance Proteins" @default.
- W2904295959 cites W1516339906 @default.
- W2904295959 cites W1595209923 @default.
- W2904295959 cites W1964056168 @default.
- W2904295959 cites W1966591303 @default.
- W2904295959 cites W1971579914 @default.
- W2904295959 cites W1972325995 @default.
- W2904295959 cites W1985547926 @default.
- W2904295959 cites W1989517413 @default.
- W2904295959 cites W1989834919 @default.
- W2904295959 cites W1999706763 @default.
- W2904295959 cites W2006434892 @default.
- W2904295959 cites W2036586732 @default.
- W2904295959 cites W2041294276 @default.
- W2904295959 cites W2059874848 @default.
- W2904295959 cites W2063095520 @default.
- W2904295959 cites W2078822262 @default.
- W2904295959 cites W2081538957 @default.
- W2904295959 cites W2082089642 @default.
- W2904295959 cites W2088686339 @default.
- W2904295959 cites W2094142039 @default.
- W2904295959 cites W2114918609 @default.
- W2904295959 cites W2118667947 @default.
- W2904295959 cites W2122492252 @default.
- W2904295959 cites W2142024216 @default.
- W2904295959 cites W2146033906 @default.
- W2904295959 cites W2153456191 @default.
- W2904295959 cites W2160121991 @default.
- W2904295959 cites W2161321562 @default.
- W2904295959 cites W2163685688 @default.
- W2904295959 cites W2169637929 @default.
- W2904295959 cites W2190066948 @default.
- W2904295959 cites W2317376153 @default.
- W2904295959 cites W2400359869 @default.
- W2904295959 cites W2551866970 @default.
- W2904295959 cites W2743017226 @default.
- W2904295959 cites W2952997691 @default.
- W2904295959 cites W4231387622 @default.
- W2904295959 doi "https://doi.org/10.1002/cmdc.201800658" @default.
- W2904295959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6476547" @default.
- W2904295959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30562414" @default.
- W2904295959 hasPublicationYear "2019" @default.
- W2904295959 type Work @default.
- W2904295959 sameAs 2904295959 @default.
- W2904295959 citedByCount "5" @default.
- W2904295959 countsByYear W29042959592020 @default.
- W2904295959 countsByYear W29042959592022 @default.
- W2904295959 countsByYear W29042959592023 @default.
- W2904295959 crossrefType "journal-article" @default.
- W2904295959 hasAuthorship W2904295959A5009000319 @default.
- W2904295959 hasAuthorship W2904295959A5013479056 @default.
- W2904295959 hasAuthorship W2904295959A5015296457 @default.
- W2904295959 hasAuthorship W2904295959A5027735851 @default.
- W2904295959 hasAuthorship W2904295959A5040489938 @default.
- W2904295959 hasAuthorship W2904295959A5041070542 @default.
- W2904295959 hasAuthorship W2904295959A5051258309 @default.
- W2904295959 hasAuthorship W2904295959A5053078484 @default.
- W2904295959 hasAuthorship W2904295959A5056602578 @default.
- W2904295959 hasAuthorship W2904295959A5058939223 @default.
- W2904295959 hasAuthorship W2904295959A5059795073 @default.
- W2904295959 hasAuthorship W2904295959A5060077054 @default.
- W2904295959 hasAuthorship W2904295959A5065954237 @default.
- W2904295959 hasAuthorship W2904295959A5069432364 @default.
- W2904295959 hasAuthorship W2904295959A5072815472 @default.
- W2904295959 hasAuthorship W2904295959A5084802244 @default.
- W2904295959 hasAuthorship W2904295959A5084829441 @default.
- W2904295959 hasBestOaLocation W29042959592 @default.
- W2904295959 hasConcept C104317684 @default.
- W2904295959 hasConcept C109316439 @default.
- W2904295959 hasConcept C133936738 @default.
- W2904295959 hasConcept C149011108 @default.
- W2904295959 hasConcept C185592680 @default.
- W2904295959 hasConcept C193042331 @default.
- W2904295959 hasConcept C202751555 @default.
- W2904295959 hasConcept C20418707 @default.
- W2904295959 hasConcept C2777667214 @default.
- W2904295959 hasConcept C44312359 @default.