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• W2904297059 endingPage "20180158" @default.
• W2904297059 startingPage "20180158" @default.
• W2904297059 abstract "In macropinocytosis, cells take up micrometre-sized droplets of medium into internal vesicles. These vesicles are acidified and fused to lysosomes, their contents digested and useful compounds extracted. Indigestible contents can be exocytosed. Macropinocytosis has been known for approaching 100 years and is described in both metazoa and amoebae, but not in plants or fungi. Its evolutionary origin goes back to at least the common ancestor of the amoebozoa and opisthokonts, with apparent secondary loss from fungi. The primary function of macropinocytosis in amoebae and some cancer cells is feeding, but the conserved processing pathway for macropinosomes, which involves shrinkage and the retrieval of membrane to the cell surface, has been adapted in immune cells for antigen presentation. Macropinocytic cups are large actin-driven processes, closely related to phagocytic cups and pseudopods and appear to be organized around a conserved signalling patch of PIP3, active Ras and active Rac that directs actin polymerization to its periphery. Patches can form spontaneously and must be sustained by excitable kinetics with strong cooperation from the actin cytoskeleton. Growth-factor signalling shares core components with macropinocytosis, based around phosphatidylinositol 3-kinase (PI3-kinase), and we suggest that it evolved to take control of ancient feeding structures through a coupled growth factor receptor. This article is part of the Theo Murphy meeting issue ‘Macropinocytosis’." @default.
• W2904297059 created "2018-12-22" @default.
• W2904297059 creator A5000350069 @default.
• W2904297059 creator A5090977575 @default.
• W2904297059 date "2018-12-17" @default.
• W2904297059 modified "2023-10-10" @default.
• W2904297059 title "The origins and evolution of macropinocytosis" @default.
• W2904297059 cites W1521770864 @default.
• W2904297059 cites W1538471627 @default.
• W2904297059 cites W1558252711 @default.
• W2904297059 cites W1561478748 @default.
• W2904297059 cites W1915414973 @default.
• W2904297059 cites W1926399189 @default.
• W2904297059 cites W1959046849 @default.
• W2904297059 cites W1969560454 @default.
• W2904297059 cites W1970012363 @default.
• W2904297059 cites W1977779210 @default.
• W2904297059 cites W1982807692 @default.
• W2904297059 cites W1982980077 @default.
• W2904297059 cites W1991147034 @default.
• W2904297059 cites W1991598168 @default.
• W2904297059 cites W2000940439 @default.
• W2904297059 cites W2001025029 @default.
• W2904297059 cites W2004084950 @default.
• W2904297059 cites W2005574904 @default.
• W2904297059 cites W2006865316 @default.
• W2904297059 cites W2007764474 @default.
• W2904297059 cites W2008682878 @default.
• W2904297059 cites W2008982597 @default.
• W2904297059 cites W2010175959 @default.
• W2904297059 cites W2015615942 @default.
• W2904297059 cites W2019304984 @default.
• W2904297059 cites W2021460799 @default.
• W2904297059 cites W2022714743 @default.
• W2904297059 cites W2023504527 @default.
• W2904297059 cites W2023670340 @default.
• W2904297059 cites W2024882507 @default.
• W2904297059 cites W2025894679 @default.
• W2904297059 cites W2027119477 @default.
• W2904297059 cites W2030122815 @default.
• W2904297059 cites W2032840486 @default.
• W2904297059 cites W2034490742 @default.
• W2904297059 cites W2039985150 @default.
• W2904297059 cites W2046002438 @default.
• W2904297059 cites W2049766220 @default.
• W2904297059 cites W2049811440 @default.
• W2904297059 cites W2049864784 @default.
• W2904297059 cites W2053270078 @default.
• W2904297059 cites W2054391174 @default.
• W2904297059 cites W2056000602 @default.
• W2904297059 cites W2058056641 @default.
• W2904297059 cites W2062609054 @default.
• W2904297059 cites W2072780871 @default.
• W2904297059 cites W2074308942 @default.
• W2904297059 cites W2077569452 @default.
• W2904297059 cites W2079357129 @default.
• W2904297059 cites W2085071119 @default.
• W2904297059 cites W2086189475 @default.
• W2904297059 cites W2087591542 @default.
• W2904297059 cites W2089144568 @default.
• W2904297059 cites W2091161919 @default.
• W2904297059 cites W2097690118 @default.
• W2904297059 cites W2099037107 @default.
• W2904297059 cites W2100030230 @default.
• W2904297059 cites W2100793782 @default.
• W2904297059 cites W2101679999 @default.
• W2904297059 cites W2102237050 @default.
• W2904297059 cites W2102337085 @default.
• W2904297059 cites W2102696072 @default.
• W2904297059 cites W2104603012 @default.
• W2904297059 cites W2106507395 @default.
• W2904297059 cites W2107095242 @default.
• W2904297059 cites W2108100159 @default.
• W2904297059 cites W2109518433 @default.
• W2904297059 cites W2110505696 @default.
• W2904297059 cites W2110984845 @default.
• W2904297059 cites W2111695773 @default.
• W2904297059 cites W2116082644 @default.
• W2904297059 cites W2122270014 @default.
• W2904297059 cites W2123778917 @default.
• W2904297059 cites W2124864193 @default.
• W2904297059 cites W2125164122 @default.
• W2904297059 cites W2126633152 @default.
• W2904297059 cites W2129917557 @default.
• W2904297059 cites W2133495202 @default.
• W2904297059 cites W2134557279 @default.
• W2904297059 cites W2138929242 @default.
• W2904297059 cites W2143719118 @default.
• W2904297059 cites W2145741262 @default.
• W2904297059 cites W2148214888 @default.
• W2904297059 cites W2150042961 @default.
• W2904297059 cites W2160431708 @default.
• W2904297059 cites W2162001000 @default.
• W2904297059 cites W2167454162 @default.
• W2904297059 cites W2168064391 @default.
• W2904297059 cites W2168698734 @default.
• W2904297059 cites W2179272349 @default.
• W2904297059 cites W2226284032 @default.

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