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- W2904297949 abstract "EphA3, a member of the Eph family of receptor tyrosine kinases, has been reported to be overexpressed in some human cancers including glioblastoma. Here, we found that expression of EphA3 is up-regulated in response to epidermal growth factor (EGF) stimulation and promotes formation of cell aggregates in suspension culture of glioblastoma cells. Suppression of EphA3 expression by short hairpin RNA-mediated knockdown or CRISPR/Cas9-mediated gene deletion inhibited EGF-induced promotion of cell aggregate formation, whereas overexpression of EphA3 promoted formation of cell aggregates in suspension culture. EGF-induced EphA3 expression and promotion of cell aggregate formation required Akt activity. Furthermore, N-cadherin, whose expression was regulated by EGF and EphA3, contributed to the formation of cell aggregates in suspension culture. These results suggest that the regulation of EphA3 expression plays a critical role in glioblastoma cell growth in non-adherent conditions." @default.
- W2904297949 created "2018-12-22" @default.
- W2904297949 creator A5015328849 @default.
- W2904297949 creator A5035165573 @default.
- W2904297949 creator A5039215121 @default.
- W2904297949 date "2019-01-01" @default.
- W2904297949 modified "2023-10-17" @default.
- W2904297949 title "EphA3 is up-regulated by epidermal growth factor and promotes formation of glioblastoma cell aggregates" @default.
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- W2904297949 doi "https://doi.org/10.1016/j.bbrc.2018.12.002" @default.
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- W2904297949 hasPublicationYear "2019" @default.
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