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- W2904306099 abstract "Abstract The integrity of thoroughbreds is maintained under strict regulation involving DNA parentage testing, which is robust in a population with high genetic variability. The genetic variability of the thoroughbred population is possibly fluctuating because of selective breeding that has focused on adaptations for racing performance. To monitor genetic variability within the population and the effectiveness of short tandem repeat (STR) parentage testing, we investigated allele frequencies and the exclusion probability (PE) of 16–17 loci of a parentage panel in the Japanese thoroughbred population over 15 years. Expected heterozygosities (He) of 14 loci indicated a decreasing trend, and the average He of the population decreased significantly. Low genetic variability was possibly induced by a decrease in population size and a selective breeding bias. Four loci showed both a significant increase in allele frequency and a significant decrease in He; it is assumed that those loci were affected by positive selection for racing performance. There was a significant decrease in the PE because of the changes in genetic variability; however, it has remained over 0.99995. The current STR panel is still effective for parentage control, but it will be necessary to continuously monitor genetic variability, which has decreased over 15 years." @default.
- W2904306099 created "2018-12-22" @default.
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- W2904306099 date "2018-12-16" @default.
- W2904306099 modified "2023-10-01" @default.
- W2904306099 title "Evaluation of recent changes in genetic variability in Japanese thoroughbred population based on a short tandem repeat parentage panel" @default.
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- W2904306099 doi "https://doi.org/10.1111/asj.13143" @default.
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