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• W2904315529 endingPage "110" @default.
• W2904315529 startingPage "110" @default.
• W2904315529 abstract "Trans-resveratrol, the most well-known polyphenolic stilbenoid, is found in grapes and accordingly in wine and it is considered to be beneficial for human health, especially towards the aging-linked cell alterations by providing numerous biological activities, such as anti-oxidant, antitumoral, antiviral, anti-inflammatory, neuroprotective, and platelet anti-aggregation properties. Although trans-resveratrol is a promising molecule, it cannot be considered as a drug, due to its weak bio-availability and fast metabolism. To overcome these weaknesses, several research teams have undertaken the synthesis of innovative trans-resveratrol derivatives, with the aim to increase its solubility in water and pharmacological activities towards cell targets. The aim of this review is to show the chronological evolution over the last 25 years of different strategies to develop more efficient trans-resveratrol derivatives towards organism physiology and, therefore, to enhance various pharmacological activities. While the literature on the development of new synthetic derivatives is impressive, this review will focus on selected strategies regarding the substitution of trans-resveratrol phenyl rings, first with hydroxy, methoxy, and halogen groups, and next with functionalized substituents. The effects on cell functions and dysfunctions of interesting resveratrol analogs will be addressed in this review." @default.
• W2904315529 created "2018-12-22" @default.
• W2904315529 creator A5063954794 @default.
• W2904315529 creator A5079787636 @default.
• W2904315529 date "2018-12-11" @default.
• W2904315529 modified "2023-09-30" @default.
• W2904315529 title "Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore their Effects on Cell Functions and Dysfunctions" @default.
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• W2904315529 doi "https://doi.org/10.3390/diseases6040110" @default.
• W2904315529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313602" @default.
• W2904315529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30545015" @default.
• W2904315529 hasPublicationYear "2018" @default.
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