Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904319062> ?p ?o ?g. }
- W2904319062 endingPage "388" @default.
- W2904319062 startingPage "377" @default.
- W2904319062 abstract "CD44 + /CD24 – phenotype has been used to identify human and canine mammary cancer stem-like cells. In canine mammary tumors, CD44 + /CD24 – phenotype has been associated with high grade and lymph node infiltration. However, several studies have reported opposing results regarding the clinical significance of phenotypic groups formed by the combination of CD44 and CD24 in both human and canine mammary tumors. So far, no study has investigated the correlation between these phenotypes and survival in dogs. The aim of this study was to investigate the expression and distribution of CD44 and CD24 in canine mammary carcinomas and to correlate them with histological diagnosis and survival in a well-characterized cohort. Immunohistochemistry was performed in 96 mammary carcinomas with antibodies against CD44 and CD24. Expression of CD44 + and CD44 + /CD24 – phenotype was detected in 75 of 96 (78%) and 63 of 96 (65.6%) carcinomas, respectively. Their expression was associated with tumor type, occurring more often in tubular complex carcinomas than in solid carcinomas. CD44 + /CD24 – phenotype was associated with a better overall survival ( P = .001). CD24 + expression was detected in 52 of 96 tumors (54%) and CD44 – /CD24 + phenotype in 39 of 96 tumors (40.6%). Both were associated with poor clinicopathological parameters (high grade, and emboli). No correlation with overall survival was observed. CD44 + /CD24 – expression was associated with a better prognosis and occurred at high frequency and high level, indicating that this phenotype is not suitable to detect cancer stem cells in canine mammary carcinomas. Although further studies are needed, our results suggest that CD24 may constitute a valuable marker of poor prognosis for canine mammary carcinomas." @default.
- W2904319062 created "2018-12-22" @default.
- W2904319062 creator A5004921691 @default.
- W2904319062 creator A5020083424 @default.
- W2904319062 creator A5029801587 @default.
- W2904319062 creator A5033724012 @default.
- W2904319062 creator A5069481900 @default.
- W2904319062 creator A5074860086 @default.
- W2904319062 creator A5078012395 @default.
- W2904319062 date "2018-12-17" @default.
- W2904319062 modified "2023-09-30" @default.
- W2904319062 title "CD44 and CD24 Expression and Prognostic Significance in Canine Mammary Tumors" @default.
- W2904319062 cites W1757407923 @default.
- W2904319062 cites W1851549694 @default.
- W2904319062 cites W1966291916 @default.
- W2904319062 cites W1972585362 @default.
- W2904319062 cites W1975680934 @default.
- W2904319062 cites W1984850374 @default.
- W2904319062 cites W1991509191 @default.
- W2904319062 cites W1993826355 @default.
- W2904319062 cites W2009886857 @default.
- W2904319062 cites W2013546397 @default.
- W2904319062 cites W2019274084 @default.
- W2904319062 cites W2022911752 @default.
- W2904319062 cites W2023427658 @default.
- W2904319062 cites W2024991678 @default.
- W2904319062 cites W2027693522 @default.
- W2904319062 cites W2034449359 @default.
- W2904319062 cites W2038948325 @default.
- W2904319062 cites W2046496538 @default.
- W2904319062 cites W2054564351 @default.
- W2904319062 cites W2056491494 @default.
- W2904319062 cites W2059182166 @default.
- W2904319062 cites W2062069198 @default.
- W2904319062 cites W2066194961 @default.
- W2904319062 cites W2070434241 @default.
- W2904319062 cites W2074282791 @default.
- W2904319062 cites W2077021628 @default.
- W2904319062 cites W2086213879 @default.
- W2904319062 cites W2092335849 @default.
- W2904319062 cites W2095782040 @default.
- W2904319062 cites W2097255042 @default.
- W2904319062 cites W2100251345 @default.
- W2904319062 cites W2102549114 @default.
- W2904319062 cites W2106619332 @default.
- W2904319062 cites W2119733072 @default.
- W2904319062 cites W2124924712 @default.
- W2904319062 cites W2131798068 @default.
- W2904319062 cites W2136178883 @default.
- W2904319062 cites W2138240181 @default.
- W2904319062 cites W2139728715 @default.
- W2904319062 cites W2139842191 @default.
- W2904319062 cites W2143383125 @default.
- W2904319062 cites W2155348198 @default.
- W2904319062 cites W2164817306 @default.
- W2904319062 cites W2166389600 @default.
- W2904319062 cites W2210937986 @default.
- W2904319062 cites W2253401643 @default.
- W2904319062 cites W2343386238 @default.
- W2904319062 cites W2478228026 @default.
- W2904319062 cites W2597667884 @default.
- W2904319062 cites W2606314496 @default.
- W2904319062 cites W2765583492 @default.
- W2904319062 cites W2765614402 @default.
- W2904319062 doi "https://doi.org/10.1177/0300985818813653" @default.
- W2904319062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30558511" @default.
- W2904319062 hasPublicationYear "2018" @default.
- W2904319062 type Work @default.
- W2904319062 sameAs 2904319062 @default.
- W2904319062 citedByCount "11" @default.
- W2904319062 countsByYear W29043190622020 @default.
- W2904319062 countsByYear W29043190622021 @default.
- W2904319062 countsByYear W29043190622022 @default.
- W2904319062 countsByYear W29043190622023 @default.
- W2904319062 crossrefType "journal-article" @default.
- W2904319062 hasAuthorship W2904319062A5004921691 @default.
- W2904319062 hasAuthorship W2904319062A5020083424 @default.
- W2904319062 hasAuthorship W2904319062A5029801587 @default.
- W2904319062 hasAuthorship W2904319062A5033724012 @default.
- W2904319062 hasAuthorship W2904319062A5069481900 @default.
- W2904319062 hasAuthorship W2904319062A5074860086 @default.
- W2904319062 hasAuthorship W2904319062A5078012395 @default.
- W2904319062 hasBestOaLocation W29043190621 @default.
- W2904319062 hasConcept C104317684 @default.
- W2904319062 hasConcept C10515644 @default.
- W2904319062 hasConcept C121608353 @default.
- W2904319062 hasConcept C126322002 @default.
- W2904319062 hasConcept C127716648 @default.
- W2904319062 hasConcept C142724271 @default.
- W2904319062 hasConcept C202751555 @default.
- W2904319062 hasConcept C204232928 @default.
- W2904319062 hasConcept C2778001805 @default.
- W2904319062 hasConcept C2779492189 @default.
- W2904319062 hasConcept C2780849966 @default.
- W2904319062 hasConcept C2780932548 @default.
- W2904319062 hasConcept C502942594 @default.
- W2904319062 hasConcept C530470458 @default.
- W2904319062 hasConcept C55493867 @default.