Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904320888> ?p ?o ?g. }
- W2904320888 abstract "Abstract Oocyte-specific miRNA function remains unclear in mice and worms because loss of Dgcr8 and Dicer from mouse and worm oocytes, respectively, does not yield oogenic defects. These data lead to several models: (a) miRNAs are not generated in oocytes; (b) miRNAs are generated but do not perform an oogenic function; (c) functional oocyte miRNAs are generated in a manner independent of these enzymes. Here, we test these models using a combination of genomic, expression and functional analyses on the C . elegans germline. We identify a repertoire of at least twenty-three miRNAs that accumulate in four spatial domains in oocytes. Genetic tests demonstrate that oocyte-expressed miRNAs regulate key oogenic processes within their respective expression domains. Unexpectedly, we find that over half of the oocyte-expressed miRNAs are generated through an unknown Drosha independent mechanism. Thus, a functional miRNA repertoire generated via Drosha dependent and independent pathways regulates C . elegans oocyte development." @default.
- W2904320888 created "2018-12-22" @default.
- W2904320888 creator A5021054045 @default.
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- W2904320888 date "2018-12-14" @default.
- W2904320888 modified "2023-10-12" @default.
- W2904320888 title "Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development" @default.
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- W2904320888 doi "https://doi.org/10.1038/s41467-018-07791-w" @default.
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