Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904320971> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2904320971 endingPage "926" @default.
- W2904320971 startingPage "921" @default.
- W2904320971 abstract "Appropriate management to prevent relapses of acquired, autoimmune thrombotic thrombocytopenic purpura (TTP) is not clear. Rituximab (375 mg/m2 /week × 4) is effective treatment for acute episodes but it is not consistently effective for prevention of relapses. Maintenance rituximab, 375 mg/m2 /3 months for 2 years, is commonly used to prevent progression of follicular lymphoma, but the outcome of maintenance rituximab to prevent TTP relapses has been rarely reported.An 8-year-old girl was diagnosed with acquired TTP in 2008; her ADAMTS13 activity was less than 5%, with a functional inhibitor of greater than 8 Bethesda units/mL. She achieved remission with therapeutic plasma exchange, corticosteroids, and rituximab (375 mg/m2 /week × 4). During the following 6 years she had seven additional episodes. Each episode responded to therapeutic plasma exchange, sometimes requiring additional treatments (corticosteroids, rituximab, and cyclophosphamide). However, these treatments, as well as splenectomy and trials of cyclophosphamide and mycophenolate mofetil during clinical remissions, failed to prevent relapses. Her ADAMTS13 activity remained 8% or less throughout all of her remissions. Maintenance rituximab was begun in 2013: 500 mg (313 mg/m2 ) every 2-3 months × 5, then 600 mg (375 mg/m2 ) every 6 months × 2. After 1 year, her ADAMTS13 was 26%; after 2 years, 51%. During the past 3 years since stopping rituximab, she has remained well, with normal ADAMTS13 activity (70%-78%).Maintenance rituximab treatment may be effective for prevention of relapses in patients with acquired, autoimmune TTP, even when splenectomy and intensive immunosuppression, including multiple conventional courses of rituximab, fail to prevent subsequent relapses." @default.
- W2904320971 created "2018-12-22" @default.
- W2904320971 creator A5006037841 @default.
- W2904320971 creator A5028673120 @default.
- W2904320971 creator A5048634068 @default.
- W2904320971 creator A5052537687 @default.
- W2904320971 date "2018-12-12" @default.
- W2904320971 modified "2023-10-05" @default.
- W2904320971 title "Maintenance rituximab for relapsing thrombotic thrombocytopenic purpura: a case report" @default.
- W2904320971 cites W1514245776 @default.
- W2904320971 cites W1910890980 @default.
- W2904320971 cites W1989736884 @default.
- W2904320971 cites W1999997909 @default.
- W2904320971 cites W2004979737 @default.
- W2904320971 cites W2013176883 @default.
- W2904320971 cites W2020578800 @default.
- W2904320971 cites W2053683902 @default.
- W2904320971 cites W2057525677 @default.
- W2904320971 cites W2059481007 @default.
- W2904320971 cites W2075575816 @default.
- W2904320971 cites W2101648653 @default.
- W2904320971 cites W2114375115 @default.
- W2904320971 cites W2114572851 @default.
- W2904320971 cites W2115270237 @default.
- W2904320971 cites W2132820210 @default.
- W2904320971 cites W2163853964 @default.
- W2904320971 cites W2192934769 @default.
- W2904320971 cites W2325858964 @default.
- W2904320971 cites W4365787119 @default.
- W2904320971 doi "https://doi.org/10.1111/trf.15093" @default.
- W2904320971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30548440" @default.
- W2904320971 hasPublicationYear "2018" @default.
- W2904320971 type Work @default.
- W2904320971 sameAs 2904320971 @default.
- W2904320971 citedByCount "6" @default.
- W2904320971 countsByYear W29043209712019 @default.
- W2904320971 countsByYear W29043209712020 @default.
- W2904320971 countsByYear W29043209712023 @default.
- W2904320971 crossrefType "journal-article" @default.
- W2904320971 hasAuthorship W2904320971A5006037841 @default.
- W2904320971 hasAuthorship W2904320971A5028673120 @default.
- W2904320971 hasAuthorship W2904320971A5048634068 @default.
- W2904320971 hasAuthorship W2904320971A5052537687 @default.
- W2904320971 hasConcept C126322002 @default.
- W2904320971 hasConcept C141071460 @default.
- W2904320971 hasConcept C2776309230 @default.
- W2904320971 hasConcept C2776694085 @default.
- W2904320971 hasConcept C2776755627 @default.
- W2904320971 hasConcept C2777878052 @default.
- W2904320971 hasConcept C2778283404 @default.
- W2904320971 hasConcept C2778585876 @default.
- W2904320971 hasConcept C2779134260 @default.
- W2904320971 hasConcept C2779338263 @default.
- W2904320971 hasConcept C2780653079 @default.
- W2904320971 hasConcept C2780921031 @default.
- W2904320971 hasConcept C2780931953 @default.
- W2904320971 hasConcept C71924100 @default.
- W2904320971 hasConcept C89560881 @default.
- W2904320971 hasConcept C90924648 @default.
- W2904320971 hasConceptScore W2904320971C126322002 @default.
- W2904320971 hasConceptScore W2904320971C141071460 @default.
- W2904320971 hasConceptScore W2904320971C2776309230 @default.
- W2904320971 hasConceptScore W2904320971C2776694085 @default.
- W2904320971 hasConceptScore W2904320971C2776755627 @default.
- W2904320971 hasConceptScore W2904320971C2777878052 @default.
- W2904320971 hasConceptScore W2904320971C2778283404 @default.
- W2904320971 hasConceptScore W2904320971C2778585876 @default.
- W2904320971 hasConceptScore W2904320971C2779134260 @default.
- W2904320971 hasConceptScore W2904320971C2779338263 @default.
- W2904320971 hasConceptScore W2904320971C2780653079 @default.
- W2904320971 hasConceptScore W2904320971C2780921031 @default.
- W2904320971 hasConceptScore W2904320971C2780931953 @default.
- W2904320971 hasConceptScore W2904320971C71924100 @default.
- W2904320971 hasConceptScore W2904320971C89560881 @default.
- W2904320971 hasConceptScore W2904320971C90924648 @default.
- W2904320971 hasIssue "3" @default.
- W2904320971 hasLocation W29043209711 @default.
- W2904320971 hasLocation W29043209712 @default.
- W2904320971 hasOpenAccess W2904320971 @default.
- W2904320971 hasPrimaryLocation W29043209711 @default.
- W2904320971 hasRelatedWork W1566884808 @default.
- W2904320971 hasRelatedWork W2075323718 @default.
- W2904320971 hasRelatedWork W2946198964 @default.
- W2904320971 hasRelatedWork W3033753898 @default.
- W2904320971 hasRelatedWork W3037949192 @default.
- W2904320971 hasRelatedWork W3104949179 @default.
- W2904320971 hasRelatedWork W3159566231 @default.
- W2904320971 hasRelatedWork W4234875595 @default.
- W2904320971 hasRelatedWork W4285801222 @default.
- W2904320971 hasRelatedWork W2036500077 @default.
- W2904320971 hasVolume "59" @default.
- W2904320971 isParatext "false" @default.
- W2904320971 isRetracted "false" @default.
- W2904320971 magId "2904320971" @default.
- W2904320971 workType "article" @default.