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- W2904321257 endingPage "6" @default.
- W2904321257 startingPage "6" @default.
- W2904321257 abstract "It is well established that cancer cells exhibit alterations in chromatin structure and accessibility. Indeed, the dysregulation of many protein-coding players with enzymatic activity (DNA and histone-modifying enzymes) and chromatin remodelers have been depicted in various tumor models in recent years. Still, little attention has been directed towards testicular germ cell tumors (TGCTs)-representing the most common neoplasm among young adult Caucasian men-with most studies focusing on exploring the role of DNA methyltransferases (DNMTs) and DNA demethylases (TETs). TGCTs represent a complex tumor model, associated with developmental and embryogenesis-related phenomena, and display seldom (cyto)genetic aberrations, leaving room for Epigenetics to explain such morphological and clinical diversity. Herein, we have summarized the major findings that were reported in literature regarding the dysregulation of DNA/histone-modifying enzymes and chromatin remodelers in TGCTs. Additionally, we performed in silico analysis of The Cancer Genome Atlas database to find the most relevant of those players in TGCTs. We concluded that several DNA/histone-modifying enzymes and chromatin remodelers may serve as biomarkers for subtyping, dictating prognosis and survival, and, possibly, for serving as targets of directed, less toxic therapies." @default.
- W2904321257 created "2018-12-22" @default.
- W2904321257 creator A5042199157 @default.
- W2904321257 creator A5057879270 @default.
- W2904321257 creator A5087200653 @default.
- W2904321257 date "2018-12-20" @default.
- W2904321257 modified "2023-09-29" @default.
- W2904321257 title "The Role of DNA/Histone Modifying Enzymes and Chromatin Remodeling Complexes in Testicular Germ Cell Tumors" @default.
- W2904321257 cites W1511164184 @default.
- W2904321257 cites W154704142 @default.
- W2904321257 cites W1578754953 @default.
- W2904321257 cites W1659536617 @default.
- W2904321257 cites W1760824447 @default.
- W2904321257 cites W1969357034 @default.
- W2904321257 cites W1984164650 @default.
- W2904321257 cites W1985557919 @default.
- W2904321257 cites W1992902970 @default.
- W2904321257 cites W2004155553 @default.
- W2904321257 cites W2005657436 @default.
- W2904321257 cites W2007462973 @default.
- W2904321257 cites W2009417248 @default.
- W2904321257 cites W2011379997 @default.
- W2904321257 cites W2019379230 @default.
- W2904321257 cites W2025277638 @default.
- W2904321257 cites W2027107904 @default.
- W2904321257 cites W2033070944 @default.
- W2904321257 cites W2034932185 @default.
- W2904321257 cites W2042037931 @default.
- W2904321257 cites W2043661576 @default.
- W2904321257 cites W2046538410 @default.
- W2904321257 cites W2049703577 @default.
- W2904321257 cites W2055158339 @default.
- W2904321257 cites W2055472916 @default.
- W2904321257 cites W2059865295 @default.
- W2904321257 cites W2061471901 @default.
- W2904321257 cites W2068518433 @default.
- W2904321257 cites W2071100938 @default.
- W2904321257 cites W2075238009 @default.
- W2904321257 cites W2076333986 @default.
- W2904321257 cites W2082330021 @default.
- W2904321257 cites W2086524378 @default.
- W2904321257 cites W2091929154 @default.
- W2904321257 cites W2092060379 @default.
- W2904321257 cites W2092791039 @default.
- W2904321257 cites W2095143857 @default.
- W2904321257 cites W2097906111 @default.
- W2904321257 cites W2101471878 @default.
- W2904321257 cites W2111964212 @default.
- W2904321257 cites W2112797367 @default.
- W2904321257 cites W2114851504 @default.
- W2904321257 cites W2122178864 @default.
- W2904321257 cites W2127180680 @default.
- W2904321257 cites W2128455188 @default.
- W2904321257 cites W2128812251 @default.
- W2904321257 cites W2133766235 @default.
- W2904321257 cites W2146329289 @default.
- W2904321257 cites W2149441684 @default.
- W2904321257 cites W2152575748 @default.
- W2904321257 cites W2153354039 @default.
- W2904321257 cites W2160206147 @default.
- W2904321257 cites W2161135419 @default.
- W2904321257 cites W2163560954 @default.
- W2904321257 cites W2163656014 @default.
- W2904321257 cites W2165971762 @default.
- W2904321257 cites W2167154785 @default.
- W2904321257 cites W2175830663 @default.
- W2904321257 cites W2227510316 @default.
- W2904321257 cites W2250212759 @default.
- W2904321257 cites W2274033784 @default.
- W2904321257 cites W2284518822 @default.
- W2904321257 cites W2287491354 @default.
- W2904321257 cites W2302403199 @default.
- W2904321257 cites W2325267338 @default.
- W2904321257 cites W2402892277 @default.
- W2904321257 cites W2433015972 @default.
- W2904321257 cites W2483690177 @default.
- W2904321257 cites W2499618563 @default.
- W2904321257 cites W2508967956 @default.
- W2904321257 cites W2538727120 @default.
- W2904321257 cites W2567185276 @default.
- W2904321257 cites W2572742978 @default.
- W2904321257 cites W2577172826 @default.
- W2904321257 cites W2591046380 @default.
- W2904321257 cites W2623719092 @default.
- W2904321257 cites W2626084238 @default.
- W2904321257 cites W2731960028 @default.
- W2904321257 cites W2736147637 @default.
- W2904321257 cites W2750821243 @default.
- W2904321257 cites W2756679114 @default.
- W2904321257 cites W2765522924 @default.
- W2904321257 cites W2770706017 @default.
- W2904321257 cites W2770953200 @default.
- W2904321257 cites W2774909726 @default.
- W2904321257 cites W2781548684 @default.
- W2904321257 cites W2788036169 @default.
- W2904321257 cites W2794508923 @default.
- W2904321257 cites W2799799484 @default.
- W2904321257 cites W2803166712 @default.