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• W2904323571 endingPage "135" @default.
• W2904323571 startingPage "125" @default.
• W2904323571 abstract "Many people use medicinal plants to relieve disorders related to the central nervous system, such as depression, epilepsy, anxiety and pain, even though the effectiveness of most of them has not yet been proven through scientific studies. Plants of the Lippia genus, Verbenaceae, are widely used in ethnobotany as a food, for seasoning and in antiseptic remedies. They are also marketed and used for the treatment of different types of pain, including stomach ache, abdominal pain and headache, as well as being used as sedatives, anxiolytics and anticonvulsants. Despite their widespread use, there are no reviews on the central nervous system profile of plants of this genus. Therefore, the databases Medline-PubMed, Embase, Scopus and Web of Science were searched using the terms Lippia and biologic activity. Thirty-five papers were found. Eleven species of Lippia showed central nervous system activity, with leaves and the aerial parts of plants being the most commonly used, especially in aqueous and ethanol extracts or volatile oil. The species are composed mainly of terpenoids and phenylpropanoids, including polyketides, flavonoids and in less quantity some alkaloids. Although several species of Lippia present analgesic activity, most studies have not explored the mechanisms responsible for this effect, however, there is some evidence that volatile oils and constituents of the extracts may be responsible for the relief of some CNS disorders, but the effects on pain modulation seem to be the most exploited so far." @default.
• W2904323571 created "2018-12-22" @default.
• W2904323571 creator A5011194708 @default.
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• W2904323571 creator A5042206009 @default.
• W2904323571 creator A5044558561 @default.
• W2904323571 creator A5047525268 @default.
• W2904323571 creator A5054485146 @default.
• W2904323571 creator A5064862069 @default.
• W2904323571 creator A5068109148 @default.
• W2904323571 creator A5086003217 @default.
• W2904323571 date "2019-01-01" @default.
• W2904323571 modified "2023-10-02" @default.
• W2904323571 title "Central nervous system and analgesic profiles of Lippia genus" @default.
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