FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904331668> ?p ?o ?g. }

• W2904331668 endingPage "562" @default.
• W2904331668 startingPage "558" @default.
• W2904331668 abstract "Carboxylesterase 1 (CES1), one of the most abundant serine hydrolases in mammals, has drawn much attentions in recent years, owing to this enzyme involves in many physiological processes via hydrolysis of both endogenous esters and xenobiotic esters. Herein, to real-time monitor the activities of CES1 in various biological systems, a practical and isoform-specific fluorescent probe was developed on the basis of the substrate preference of CES1, as well as the structural and optical properties of BODIPY dyes. After screening of a panel of BODIPY ester derivatives, probe 1 displayed the best combination of specificity, sensitivity, enzymatic kinetics and applicability for monitoring CES1 activities in real samples. This probe was successfully used to detect CES1 activities in several biological systems including tissue preparations, living cells, tissue slices and zebrafish. Furthermore, the biomedical applications of probe 1 for screening of CES1 inhibitors were also demonstrated using tissue preparations or living cells as enzyme sources. In summary, a practical and broadly applicable tool for real-time monitoring CES1 in biological systems was developed and well-characterized, which held great promise for further investigations on CES1-associated drug discovery, clinical practice and fundamental research." @default.
• W2904331668 created "2018-12-22" @default.
• W2904331668 creator A5004775159 @default.
• W2904331668 creator A5008654435 @default.
• W2904331668 creator A5022495891 @default.
• W2904331668 creator A5030220855 @default.
• W2904331668 creator A5044490427 @default.
• W2904331668 creator A5050920786 @default.
• W2904331668 creator A5056195164 @default.
• W2904331668 creator A5056257531 @default.
• W2904331668 creator A5072274987 @default.
• W2904331668 creator A5075203300 @default.
• W2904331668 creator A5091068751 @default.
• W2904331668 date "2019-03-01" @default.
• W2904331668 modified "2023-10-16" @default.
• W2904331668 title "Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe" @default.
• W2904331668 cites W1647840255 @default.
• W2904331668 cites W1959564014 @default.
• W2904331668 cites W1984628553 @default.
• W2904331668 cites W1996095828 @default.
• W2904331668 cites W1997855068 @default.
• W2904331668 cites W2003147329 @default.
• W2904331668 cites W2007159204 @default.
• W2904331668 cites W2019387110 @default.
• W2904331668 cites W2022465511 @default.
• W2904331668 cites W2036903033 @default.
• W2904331668 cites W2037248257 @default.
• W2904331668 cites W2054339027 @default.
• W2904331668 cites W2054650621 @default.
• W2904331668 cites W2060291899 @default.
• W2904331668 cites W2113981935 @default.
• W2904331668 cites W2115535678 @default.
• W2904331668 cites W2126994709 @default.
• W2904331668 cites W2142838317 @default.
• W2904331668 cites W2151843654 @default.
• W2904331668 cites W2161672948 @default.
• W2904331668 cites W2172572999 @default.
• W2904331668 cites W2338439820 @default.
• W2904331668 cites W2344749353 @default.
• W2904331668 cites W2468789868 @default.
• W2904331668 cites W2484319716 @default.
• W2904331668 cites W2557364141 @default.
• W2904331668 cites W2565425661 @default.
• W2904331668 cites W2581780524 @default.
• W2904331668 cites W2739556118 @default.
• W2904331668 cites W2748752729 @default.
• W2904331668 cites W2749724577 @default.
• W2904331668 cites W2750940372 @default.
• W2904331668 cites W2754028974 @default.
• W2904331668 cites W2772017860 @default.
• W2904331668 cites W2793375121 @default.
• W2904331668 cites W2793376062 @default.
• W2904331668 cites W2810653208 @default.
• W2904331668 cites W2884620081 @default.
• W2904331668 cites W907579459 @default.
• W2904331668 doi "https://doi.org/10.1016/j.cclet.2018.12.013" @default.
• W2904331668 hasPublicationYear "2019" @default.
• W2904331668 type Work @default.
• W2904331668 sameAs 2904331668 @default.
• W2904331668 citedByCount "26" @default.
• W2904331668 countsByYear W29043316682019 @default.
• W2904331668 countsByYear W29043316682020 @default.
• W2904331668 countsByYear W29043316682021 @default.
• W2904331668 countsByYear W29043316682022 @default.
• W2904331668 countsByYear W29043316682023 @default.
• W2904331668 crossrefType "journal-article" @default.
• W2904331668 hasAuthorship W2904331668A5004775159 @default.
• W2904331668 hasAuthorship W2904331668A5008654435 @default.
• W2904331668 hasAuthorship W2904331668A5022495891 @default.
• W2904331668 hasAuthorship W2904331668A5030220855 @default.
• W2904331668 hasAuthorship W2904331668A5044490427 @default.
• W2904331668 hasAuthorship W2904331668A5050920786 @default.
• W2904331668 hasAuthorship W2904331668A5056195164 @default.
• W2904331668 hasAuthorship W2904331668A5056257531 @default.
• W2904331668 hasAuthorship W2904331668A5072274987 @default.
• W2904331668 hasAuthorship W2904331668A5075203300 @default.
• W2904331668 hasAuthorship W2904331668A5091068751 @default.
• W2904331668 hasConcept C104317684 @default.
• W2904331668 hasConcept C115448650 @default.
• W2904331668 hasConcept C121332964 @default.
• W2904331668 hasConcept C181199279 @default.
• W2904331668 hasConcept C185592680 @default.
• W2904331668 hasConcept C18903297 @default.
• W2904331668 hasConcept C2776878037 @default.
• W2904331668 hasConcept C2777289219 @default.
• W2904331668 hasConcept C2781374752 @default.
• W2904331668 hasConcept C53345823 @default.
• W2904331668 hasConcept C55493867 @default.
• W2904331668 hasConcept C62520636 @default.
• W2904331668 hasConcept C70721500 @default.
• W2904331668 hasConcept C86803240 @default.
• W2904331668 hasConcept C91881484 @default.
• W2904331668 hasConceptScore W2904331668C104317684 @default.
• W2904331668 hasConceptScore W2904331668C115448650 @default.
• W2904331668 hasConceptScore W2904331668C121332964 @default.
• W2904331668 hasConceptScore W2904331668C181199279 @default.
• W2904331668 hasConceptScore W2904331668C185592680 @default.
• W2904331668 hasConceptScore W2904331668C18903297 @default.

• next