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- W2904340860 abstract "Abstract The Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection." @default.
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- W2904340860 date "2018-11-24" @default.
- W2904340860 modified "2023-10-09" @default.
- W2904340860 title "Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model" @default.
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- W2904340860 doi "https://doi.org/10.1093/mmy/myy112" @default.
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