Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904344461> ?p ?o ?g. }
- W2904344461 abstract "Abstract IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4 + T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3 neg CD4 + T cells that displays regulatory activity unlike other IL-10-producing CD4 + T cells, which are unexpectedly pro-inflammatory. The combinatorial expression of co-inhibitory receptors is sufficient to discriminate IL-10-producing CD4 + T cells with regulatory function from others and to identify them across different tissues and disease models in mice and humans. These regulatory IL-10-producing Foxp3 neg CD4 + T cells have a unique transcriptional program, which goes beyond the regulation of IL-10 expression. Finally, we found that patients with Inflammatory Bowel Disease demonstrate a deficiency in this specific regulatory T-cell subpopulation." @default.
- W2904344461 created "2018-12-22" @default.
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- W2904344461 date "2018-12-21" @default.
- W2904344461 modified "2023-10-06" @default.
- W2904344461 title "Molecular and functional heterogeneity of IL-10-producing CD4+ T cells" @default.
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