Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904346898> ?p ?o ?g. }
- W2904346898 endingPage "564" @default.
- W2904346898 startingPage "554" @default.
- W2904346898 abstract "Emerging research has indicated that circular RNAs (circRNAs), a novel class of non-coding RNAs, play a vital role in human tumorigenesis and progression. Our previous results suggested that hsa_circ_0006528 (circ_0006528), a circRNA with an unknown function, mediates adriamycin resistance in human breast cancer cells. However, the role of circ_0006528 in breast cancer progression remains unknown. Here, we investigated the probable involvement of circ_0006528 in breast cancer. We analyzed a cohort of 97 patients and found that circ_0006528 expression was significantly upregulated in human breast cancer tissues compared with that in adjacent non-tumorous tissues and was significantly associated with advanced tumor-node-metastasis (TNM) stage and poor prognosis. In addition, we found that in breast cancer cells, circ_0006528 could promote DNA synthesis and cell proliferation, invasion, and migration. Downregulating circ_0006528 induced G2 phase arrest and cell apoptosis. Further mechanistic studies revealed that circ_0006528 could sponge endogenous miR-7-5p and inhibit its activity. We also identified Raf1, which activates the MAPK/ERK signaling pathway, as a target of miR-7-5p and determined that circ_0006528 promotes breast cancer growth, invasion, and migration by promoting the expression of Raf1 and activates the MAPK/ERK pathway. Thus, this study provides the first evidence of the circ_0006528/miR-7-5p/Raf1/MEK/ERK regulatory network in the development of breast cancer and suggests that circ_0006528 is a potential therapeutic target and prognostic predictor for breast cancer." @default.
- W2904346898 created "2018-12-22" @default.
- W2904346898 creator A5033662483 @default.
- W2904346898 creator A5040867903 @default.
- W2904346898 creator A5047774974 @default.
- W2904346898 creator A5059430503 @default.
- W2904346898 creator A5069275626 @default.
- W2904346898 creator A5079396252 @default.
- W2904346898 date "2018-12-21" @default.
- W2904346898 modified "2023-10-16" @default.
- W2904346898 title "hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway" @default.
- W2904346898 cites W1648301895 @default.
- W2904346898 cites W1866220599 @default.
- W2904346898 cites W1894780382 @default.
- W2904346898 cites W1971623350 @default.
- W2904346898 cites W1980379052 @default.
- W2904346898 cites W2006986876 @default.
- W2904346898 cites W2011826559 @default.
- W2904346898 cites W2011938376 @default.
- W2904346898 cites W2042865509 @default.
- W2904346898 cites W2046387002 @default.
- W2904346898 cites W2057259698 @default.
- W2904346898 cites W2058835062 @default.
- W2904346898 cites W2060630008 @default.
- W2904346898 cites W2064165694 @default.
- W2904346898 cites W2070291618 @default.
- W2904346898 cites W2083836886 @default.
- W2904346898 cites W2088128227 @default.
- W2904346898 cites W2092180337 @default.
- W2904346898 cites W2093921289 @default.
- W2904346898 cites W2122231684 @default.
- W2904346898 cites W2137343216 @default.
- W2904346898 cites W2159054485 @default.
- W2904346898 cites W2159790659 @default.
- W2904346898 cites W2219781244 @default.
- W2904346898 cites W2266356262 @default.
- W2904346898 cites W2302185643 @default.
- W2904346898 cites W2331419903 @default.
- W2904346898 cites W2332619026 @default.
- W2904346898 cites W2410272781 @default.
- W2904346898 cites W2509105303 @default.
- W2904346898 cites W2510861800 @default.
- W2904346898 cites W2511817459 @default.
- W2904346898 cites W2520910545 @default.
- W2904346898 cites W2573032256 @default.
- W2904346898 cites W2581834730 @default.
- W2904346898 cites W2590279460 @default.
- W2904346898 cites W2591096977 @default.
- W2904346898 cites W2594574412 @default.
- W2904346898 cites W2621113699 @default.
- W2904346898 cites W2730963455 @default.
- W2904346898 cites W2747105326 @default.
- W2904346898 cites W2757138400 @default.
- W2904346898 doi "https://doi.org/10.1002/mc.22950" @default.
- W2904346898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30520151" @default.
- W2904346898 hasPublicationYear "2018" @default.
- W2904346898 type Work @default.
- W2904346898 sameAs 2904346898 @default.
- W2904346898 citedByCount "98" @default.
- W2904346898 countsByYear W29043468982019 @default.
- W2904346898 countsByYear W29043468982020 @default.
- W2904346898 countsByYear W29043468982021 @default.
- W2904346898 countsByYear W29043468982022 @default.
- W2904346898 countsByYear W29043468982023 @default.
- W2904346898 crossrefType "journal-article" @default.
- W2904346898 hasAuthorship W2904346898A5033662483 @default.
- W2904346898 hasAuthorship W2904346898A5040867903 @default.
- W2904346898 hasAuthorship W2904346898A5047774974 @default.
- W2904346898 hasAuthorship W2904346898A5059430503 @default.
- W2904346898 hasAuthorship W2904346898A5069275626 @default.
- W2904346898 hasAuthorship W2904346898A5079396252 @default.
- W2904346898 hasConcept C104317684 @default.
- W2904346898 hasConcept C121608353 @default.
- W2904346898 hasConcept C127561419 @default.
- W2904346898 hasConcept C145059251 @default.
- W2904346898 hasConcept C2779013556 @default.
- W2904346898 hasConcept C2779256057 @default.
- W2904346898 hasConcept C502942594 @default.
- W2904346898 hasConcept C530470458 @default.
- W2904346898 hasConcept C54355233 @default.
- W2904346898 hasConcept C555283112 @default.
- W2904346898 hasConcept C57074206 @default.
- W2904346898 hasConcept C60365752 @default.
- W2904346898 hasConcept C62112901 @default.
- W2904346898 hasConcept C62203573 @default.
- W2904346898 hasConcept C62478195 @default.
- W2904346898 hasConcept C86803240 @default.
- W2904346898 hasConcept C95444343 @default.
- W2904346898 hasConceptScore W2904346898C104317684 @default.
- W2904346898 hasConceptScore W2904346898C121608353 @default.
- W2904346898 hasConceptScore W2904346898C127561419 @default.
- W2904346898 hasConceptScore W2904346898C145059251 @default.
- W2904346898 hasConceptScore W2904346898C2779013556 @default.
- W2904346898 hasConceptScore W2904346898C2779256057 @default.
- W2904346898 hasConceptScore W2904346898C502942594 @default.
- W2904346898 hasConceptScore W2904346898C530470458 @default.
- W2904346898 hasConceptScore W2904346898C54355233 @default.
- W2904346898 hasConceptScore W2904346898C555283112 @default.