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- W2904349916 abstract "This thesis reports the types of glycosaminoglycans (GAGs) important for the Lyme disease pathogen Borrelia burgdorferi interactions with endothelial cells under physiological shear stress. Contributions of specific GAG classes to bacterial interactions was assessed in flow chamber devices through competitive inhibition with soluble GAGs and depletion of GAGs with deglycosylation enzymes. A broad range of GAGs were found to mediate interactions of infectious B. burgdorferi with endothelial cells under shear stress. B. burgdorferi tethering interactions were dependent on all GAG types tested, while dragging interactions were mediated by a more restricted range of GAG types. Stationary adhesions were stimulated by highly charged exogenous GAGs but were not found to be GAG-dependent. BBK32 B. burgdorferi vascular adhesin-mediated tethering interactions were heparin-dependent, while BBK32-mediated dragging interactions were not GAG-dependent. Together, this data represents the shear-tolerant binding of B. burgdorferi with specific GAG classes and offers a potential molecular mechanism of pathogen-host interaction.%%%%M.Sc." @default.
- W2904349916 created "2018-12-22" @default.
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- W2904349916 date "2018-03-01" @default.
- W2904349916 modified "2023-09-23" @default.
- W2904349916 title "Glycosylation features mediating endothelial interactions of the Lyme disease pathogen Borrelia burgdorferi" @default.
- W2904349916 hasPublicationYear "2018" @default.
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