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• W2904359944 abstract "This first‐in‐man study was carried out to evaluate the safety, whole‐body distribution, dose estimation, and lesion accumulation of 18 F‐ FSU ‐880, a newly developed probe targeting prostate‐specific membrane antigen. Six prostate cancer patients with known metastatic lesions underwent serial whole‐body PET/computed tomography ( CT ) with 18 F‐ FSU ‐880. Blood and urine were analyzed before and after PET / CT . Accumulation of 18 F‐ FSU ‐880 in organs and metastatic lesions in serial PET images were evaluated by measuring the standardized uptake values. From the biodistribution data, the organ doses and whole‐body effective dose were calculated using OLINDA / EXM software was developed by Dr. Michael Stabin of Vanderbilt University, Nashville, Tennessee, USA. 18 F‐ FSU ‐880 PET / CT could be carried out without significant adverse effects. High physiological uptake was observed in the salivary/lachrymal glands and kidneys. The effective dose was calculated to be 0.921 × 10 −2 mS v/ MB q. Known metastatic lesions were clearly visualized with high image contrast that increased with time, except in 1 patient, whose bone metastases were well‐controlled and inactive. The PET / CT with 18 F‐ FSU ‐880 could be carried out safely and could clearly visualize active metastatic lesions. The present results warrant further clinical studies with a larger number of cases to verify the clinical utility of 18 F‐ FSU ‐880 PET / CT in the management of prostate cancer patients." @default.
• W2904359944 created "2018-12-22" @default.
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• W2904359944 date "2019-01-04" @default.
• W2904359944 modified "2023-10-14" @default.
• W2904359944 title "Initial evaluation of <scp>PET</scp> / <scp>CT</scp> with ¹⁸ F‐ <scp>FSU</scp> ‐880 targeting prostate‐specific membrane antigen in prostate cancer patients" @default.
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• W2904359944 doi "https://doi.org/10.1111/cas.13911" @default.
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