Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904365799> ?p ?o ?g. }
- W2904365799 abstract "Abstract It is common that one medication is prescribed for several indications, and conversely that several medications are prescribed for the same indication, suggesting a complex biological network for disease risk and its relationship with pharmacological function. Genome-wide association studies (GWASs) of medication-use may contribute to understanding of disease etiology, generation of new leads relevant for drug discovery and quantify prospects for precision medicine. We conducted GWAS to profile self-reported medication-use from 23 categories in approximately 320,000 individuals from the UK Biobank. A total of 505 independent genetic loci that met stringent criteria for statistical significance were identified. We investigated the implications of these GWAS findings in relation to biological mechanism, drug target identification and genetic risk stratification of disease. Amongst the medication-associated genes were 16 known therapeutic-effect target genes for medications from 9 categories." @default.
- W2904365799 created "2018-12-22" @default.
- W2904365799 creator A5002628620 @default.
- W2904365799 creator A5013314246 @default.
- W2904365799 creator A5020502354 @default.
- W2904365799 creator A5021583132 @default.
- W2904365799 creator A5025712490 @default.
- W2904365799 creator A5052411434 @default.
- W2904365799 creator A5054249391 @default.
- W2904365799 creator A5059130096 @default.
- W2904365799 creator A5064741640 @default.
- W2904365799 date "2018-12-20" @default.
- W2904365799 modified "2023-10-16" @default.
- W2904365799 title "Genetic analyses of medication-use and implications for precision medicine" @default.
- W2904365799 cites W1533942137 @default.
- W2904365799 cites W1980996290 @default.
- W2904365799 cites W1998977949 @default.
- W2904365799 cites W2033151532 @default.
- W2904365799 cites W2041073071 @default.
- W2904365799 cites W2051314902 @default.
- W2904365799 cites W2067273260 @default.
- W2904365799 cites W2072789685 @default.
- W2904365799 cites W2082704080 @default.
- W2904365799 cites W2101605059 @default.
- W2904365799 cites W2118822739 @default.
- W2904365799 cites W2121926780 @default.
- W2904365799 cites W2125972459 @default.
- W2904365799 cites W2130410032 @default.
- W2904365799 cites W2135199713 @default.
- W2904365799 cites W2150845035 @default.
- W2904365799 cites W2152885121 @default.
- W2904365799 cites W2153118028 @default.
- W2904365799 cites W2153860431 @default.
- W2904365799 cites W2195783463 @default.
- W2904365799 cites W2207883841 @default.
- W2904365799 cites W2214074259 @default.
- W2904365799 cites W2315582431 @default.
- W2904365799 cites W2328393125 @default.
- W2904365799 cites W2341504574 @default.
- W2904365799 cites W2397340449 @default.
- W2904365799 cites W2400849275 @default.
- W2904365799 cites W2558217333 @default.
- W2904365799 cites W2558999090 @default.
- W2904365799 cites W2576399021 @default.
- W2904365799 cites W2581452190 @default.
- W2904365799 cites W2592785564 @default.
- W2904365799 cites W2612467560 @default.
- W2904365799 cites W2612591211 @default.
- W2904365799 cites W2725988230 @default.
- W2904365799 cites W2752584372 @default.
- W2904365799 cites W2756968234 @default.
- W2904365799 cites W2791561883 @default.
- W2904365799 cites W2949543964 @default.
- W2904365799 cites W2951276412 @default.
- W2904365799 cites W2953357410 @default.
- W2904365799 doi "https://doi.org/10.1101/501049" @default.
- W2904365799 hasPublicationYear "2018" @default.
- W2904365799 type Work @default.
- W2904365799 sameAs 2904365799 @default.
- W2904365799 citedByCount "0" @default.
- W2904365799 crossrefType "posted-content" @default.
- W2904365799 hasAuthorship W2904365799A5002628620 @default.
- W2904365799 hasAuthorship W2904365799A5013314246 @default.
- W2904365799 hasAuthorship W2904365799A5020502354 @default.
- W2904365799 hasAuthorship W2904365799A5021583132 @default.
- W2904365799 hasAuthorship W2904365799A5025712490 @default.
- W2904365799 hasAuthorship W2904365799A5052411434 @default.
- W2904365799 hasAuthorship W2904365799A5054249391 @default.
- W2904365799 hasAuthorship W2904365799A5059130096 @default.
- W2904365799 hasAuthorship W2904365799A5064741640 @default.
- W2904365799 hasBestOaLocation W29043657991 @default.
- W2904365799 hasConcept C104317684 @default.
- W2904365799 hasConcept C106208931 @default.
- W2904365799 hasConcept C111472728 @default.
- W2904365799 hasConcept C116567970 @default.
- W2904365799 hasConcept C116834253 @default.
- W2904365799 hasConcept C126322002 @default.
- W2904365799 hasConcept C135763542 @default.
- W2904365799 hasConcept C137627325 @default.
- W2904365799 hasConcept C138885662 @default.
- W2904365799 hasConcept C153209595 @default.
- W2904365799 hasConcept C163763905 @default.
- W2904365799 hasConcept C186413461 @default.
- W2904365799 hasConcept C2779134260 @default.
- W2904365799 hasConcept C2780035454 @default.
- W2904365799 hasConcept C54355233 @default.
- W2904365799 hasConcept C59822182 @default.
- W2904365799 hasConcept C60644358 @default.
- W2904365799 hasConcept C70721500 @default.
- W2904365799 hasConcept C71924100 @default.
- W2904365799 hasConcept C86803240 @default.
- W2904365799 hasConcept C89611455 @default.
- W2904365799 hasConcept C98274493 @default.
- W2904365799 hasConceptScore W2904365799C104317684 @default.
- W2904365799 hasConceptScore W2904365799C106208931 @default.
- W2904365799 hasConceptScore W2904365799C111472728 @default.
- W2904365799 hasConceptScore W2904365799C116567970 @default.
- W2904365799 hasConceptScore W2904365799C116834253 @default.
- W2904365799 hasConceptScore W2904365799C126322002 @default.
- W2904365799 hasConceptScore W2904365799C135763542 @default.