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- W2904371741 startingPage "88" @default.
- W2904371741 abstract "Autism Spectrum Disorder (ASD) is a category of neurodevelopmental disturbances seriously affecting social skills, to which the scientific community has paid great attention in last decades. To date, their pathogenesis is still unknown, but several studies highlighted the relevance of gene-environment interactions in the onset of ASD. In addition, an immune involvement was seen in a wide number of ASD subjects, leading several researchers to hypothesize a possible common pathogenesis between ASD and immune disturbances, including Atopic Dermatitis (AD). In general, among potential contributing factors, microRNAs (miRNAs), small molecules capable of controlling gene expression and targeting mRNA transcripts, might represent one of the major circulating link, possibly unraveling the connections between neurodevelopmental and immune conditions. Under such premises, we conducted a systematic literature review, under the PRISMA guidelines, trying to define the panel of common miRNAs involved in both ASD and AD. The review retrieved articles published between January 1, 2005, and December 13, 2018, in PubMed, ScienceDirect, PsycARTICLES, and Google Scholar. We found a handful of works dealing with miRNAs in ASD and AD, with the most overlapping dysregulated miRNAs being miR-146 and miR-155. Two possible compounds are abnormally regulated in both ASD and AD subjects, possibly cross-contributing to the interactions between the two disorders, setting the basis to investigate more precisely the possible link between ASD and AD from another, not just clinical, perspective." @default.
- W2904371741 created "2018-12-22" @default.
- W2904371741 creator A5002487223 @default.
- W2904371741 creator A5028294961 @default.
- W2904371741 creator A5068357190 @default.
- W2904371741 creator A5069155778 @default.
- W2904371741 creator A5072546849 @default.
- W2904371741 creator A5080312255 @default.
- W2904371741 creator A5088192604 @default.
- W2904371741 date "2019-01-14" @default.
- W2904371741 modified "2023-10-18" @default.
- W2904371741 title "MicroRNA Cross-Involvement in Autism Spectrum Disorders and Atopic Dermatitis: A Literature Review" @default.
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