FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904382377> ?p ?o ?g. }

• W2904382377 endingPage "3745" @default.
• W2904382377 startingPage "3731" @default.
• W2904382377 abstract "In the current study, we explored the impact of Tudor-staphylococcal nuclease (SN) on obesity induced by a high-fat diet (HFD) in mice, because the functional involvement of Tudor-SN in lipid metabolism in vivo is unknown. HFD-transgenic (Tg) mice exhibited reductions in hepatic steatosis and systemic insulin resistance. There was no difference in hepatic lipid accumulation between chow-fed wild-type (WT) and chow-fed Tg mice; consistently, no difference in activation of the lipogenic pathway was detected. Overactivation of hepatic nuclear sterol regulatory element-binding protein (nSrebp2)-2, the central regulator of cholesterol metabolic proteins, was observed in HFD-Tg livers along with improved cholesterol homeostasis, but no such changes were observed in HFD-WT livers. Consistent results were observed in vitro in α-mouse liver 12 cells treated with palmitate mimicking the HFD state. In addition, global gene analysis indicated that various downstream targets of nSrebp2, were up-regulated in HFD-Tg livers. Moreover, HFD-WT mice displayed islet hypertrophy and suppression of glucose-induced insulin secretion from islets, whereas HFD-Tg mice had normal pancreatic islets. This finding suggests that the improved pancreatic metabolism of HFD-Tg mice is related to the systemic effect of insulin resistance, not to the autonomous influence of pancreatic cells. Tudor-SN is likely to be a key regulator for ameliorating HFD-induced hepatic steatosis and systemic insulin resistance in vivo.-Wang, X., Xin, L., Duan, Z., Zuo, Z., Wang, Y., Ren, Y., Zhang, W., Sun, X., Liu, X., Ge, L., Yang, X., Yao, Z., Yang, J. Global Tudor-SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance." @default.
• W2904382377 created "2018-12-22" @default.
• W2904382377 creator A5005159202 @default.
• W2904382377 creator A5005391697 @default.
• W2904382377 creator A5009878349 @default.
• W2904382377 creator A5020041888 @default.
• W2904382377 creator A5021687717 @default.
• W2904382377 creator A5030977495 @default.
• W2904382377 creator A5034689364 @default.
• W2904382377 creator A5040299035 @default.
• W2904382377 creator A5044944905 @default.
• W2904382377 creator A5067635839 @default.
• W2904382377 creator A5073582581 @default.
• W2904382377 creator A5089053178 @default.
• W2904382377 creator A5091035103 @default.
• W2904382377 date "2018-12-06" @default.
• W2904382377 modified "2023-10-11" @default.
• W2904382377 title "Global Tudor‐SN transgenic mice are protected from obesity‐induced hepatic steatosis and insulin resistance" @default.
• W2904382377 cites W1507216163 @default.
• W2904382377 cites W1598254642 @default.
• W2904382377 cites W1696472482 @default.
• W2904382377 cites W1969734540 @default.
• W2904382377 cites W1973939264 @default.
• W2904382377 cites W1980867561 @default.
• W2904382377 cites W1995289527 @default.
• W2904382377 cites W2009173540 @default.
• W2904382377 cites W2012295774 @default.
• W2904382377 cites W2021678284 @default.
• W2904382377 cites W2026241394 @default.
• W2904382377 cites W2027521216 @default.
• W2904382377 cites W2028100966 @default.
• W2904382377 cites W2037136715 @default.
• W2904382377 cites W2046449500 @default.
• W2904382377 cites W2048052210 @default.
• W2904382377 cites W2052135705 @default.
• W2904382377 cites W2053181794 @default.
• W2904382377 cites W2057953609 @default.
• W2904382377 cites W2060439860 @default.
• W2904382377 cites W2064582293 @default.
• W2904382377 cites W2083493656 @default.
• W2904382377 cites W2086102771 @default.
• W2904382377 cites W2109371472 @default.
• W2904382377 cites W2123231186 @default.
• W2904382377 cites W2138307264 @default.
• W2904382377 cites W2138486337 @default.
• W2904382377 cites W2147004068 @default.
• W2904382377 cites W2160654483 @default.
• W2904382377 cites W2168436114 @default.
• W2904382377 cites W2168854535 @default.
• W2904382377 cites W2170215481 @default.
• W2904382377 cites W2256534726 @default.
• W2904382377 cites W2288744531 @default.
• W2904382377 cites W2334133751 @default.
• W2904382377 cites W2407570034 @default.
• W2904382377 cites W2508256399 @default.
• W2904382377 cites W2526400916 @default.
• W2904382377 cites W2566301136 @default.
• W2904382377 cites W2592123165 @default.
• W2904382377 cites W2791600443 @default.
• W2904382377 cites W4252021281 @default.
• W2904382377 doi "https://doi.org/10.1096/fj.201801253rr" @default.
• W2904382377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30521378" @default.
• W2904382377 hasPublicationYear "2018" @default.
• W2904382377 type Work @default.
• W2904382377 sameAs 2904382377 @default.
• W2904382377 citedByCount "3" @default.
• W2904382377 countsByYear W29043823772020 @default.
• W2904382377 countsByYear W29043823772021 @default.
• W2904382377 crossrefType "journal-article" @default.
• W2904382377 hasAuthorship W2904382377A5005159202 @default.
• W2904382377 hasAuthorship W2904382377A5005391697 @default.
• W2904382377 hasAuthorship W2904382377A5009878349 @default.
• W2904382377 hasAuthorship W2904382377A5020041888 @default.
• W2904382377 hasAuthorship W2904382377A5021687717 @default.
• W2904382377 hasAuthorship W2904382377A5030977495 @default.
• W2904382377 hasAuthorship W2904382377A5034689364 @default.
• W2904382377 hasAuthorship W2904382377A5040299035 @default.
• W2904382377 hasAuthorship W2904382377A5044944905 @default.
• W2904382377 hasAuthorship W2904382377A5067635839 @default.
• W2904382377 hasAuthorship W2904382377A5073582581 @default.
• W2904382377 hasAuthorship W2904382377A5089053178 @default.
• W2904382377 hasAuthorship W2904382377A5091035103 @default.
• W2904382377 hasConcept C102230213 @default.
• W2904382377 hasConcept C104317684 @default.
• W2904382377 hasConcept C126322002 @default.
• W2904382377 hasConcept C134018914 @default.
• W2904382377 hasConcept C141035611 @default.
• W2904382377 hasConcept C165220095 @default.
• W2904382377 hasConcept C185592680 @default.
• W2904382377 hasConcept C2776175330 @default.
• W2904382377 hasConcept C2777391703 @default.
• W2904382377 hasConcept C2779306644 @default.
• W2904382377 hasConcept C2779855799 @default.
• W2904382377 hasConcept C3018667095 @default.
• W2904382377 hasConcept C4733338 @default.
• W2904382377 hasConcept C55493867 @default.
• W2904382377 hasConcept C71924100 @default.
• W2904382377 hasConcept C86803240 @default.

• next