Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904383504> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2904383504 endingPage "169" @default.
- W2904383504 startingPage "161" @default.
- W2904383504 abstract "Background: Hepatocellular carcinoma is one of the most common malignant tumors, with rapid development and high malignancy. MicroRNAs have been reported to play important roles in hepatocellular carcinoma progression. Aim: To identify the key genes and miRNAs in HCC, and to explore their potential molecular mechanisms. Methods: Gene expression profiles of GSE15471 (mRNA profile) and GSE57555 (miRNA profile) were downloaded from gene expression omnibus, which were analysed using R software and bioconductor packages. The gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichments of DEGs were performed using the DAVID database, and the protein–protein interaction networks of the DEGs were constructed from the STRING database. In addition, targets of differentially expressed miRNAs were predicted by the online resource miRDB. Result: In total, 191 differentially expressed genes were identified, including 142 upregulated and 49 downregulated genes. Functional analysis revealed that these DEGs were associates with wound healing, endodermal cell-cell adhesion, activation of MAPK activity and negative regulation of cell proliferation. In addition, we identified five DEMs, which were upregulated and downregulated. hsa-miR-122-5p may target the PDK4, and hsa-miR-21-5p probably targets SPOCK1 and PAIP2B. Conclusions: We applied integrated bioinformatics to identify key pathogenic genes involved in hepatocellular carcinoma and provide new clues for further studies of hepatocellular carcinoma." @default.
- W2904383504 created "2018-12-22" @default.
- W2904383504 creator A5042838941 @default.
- W2904383504 creator A5053402281 @default.
- W2904383504 creator A5054305024 @default.
- W2904383504 creator A5087121087 @default.
- W2904383504 date "2018-11-20" @default.
- W2904383504 modified "2023-09-25" @default.
- W2904383504 title "Expression Profiles Analysis Identification and Interaction of Key Genes and Micrornas in Hepatocellular Carcinoma" @default.
- W2904383504 cites W1990065094 @default.
- W2904383504 cites W1991429659 @default.
- W2904383504 cites W1992941735 @default.
- W2904383504 cites W2070934882 @default.
- W2904383504 cites W2151196497 @default.
- W2904383504 cites W2306038312 @default.
- W2904383504 cites W2337934908 @default.
- W2904383504 cites W2566718902 @default.
- W2904383504 cites W2574569679 @default.
- W2904383504 cites W2613437609 @default.
- W2904383504 cites W2622465088 @default.
- W2904383504 cites W2780312060 @default.
- W2904383504 cites W2791547506 @default.
- W2904383504 cites W2796220975 @default.
- W2904383504 cites W2807088512 @default.
- W2904383504 cites W2808061953 @default.
- W2904383504 cites W2810690816 @default.
- W2904383504 cites W2822141983 @default.
- W2904383504 cites W2883611688 @default.
- W2904383504 cites W2884545244 @default.
- W2904383504 cites W2888247535 @default.
- W2904383504 cites W2888464037 @default.
- W2904383504 cites W2889202557 @default.
- W2904383504 doi "https://doi.org/10.31586/biomedicine.0304.03" @default.
- W2904383504 hasPublicationYear "2018" @default.
- W2904383504 type Work @default.
- W2904383504 sameAs 2904383504 @default.
- W2904383504 citedByCount "0" @default.
- W2904383504 crossrefType "journal-article" @default.
- W2904383504 hasAuthorship W2904383504A5042838941 @default.
- W2904383504 hasAuthorship W2904383504A5053402281 @default.
- W2904383504 hasAuthorship W2904383504A5054305024 @default.
- W2904383504 hasAuthorship W2904383504A5087121087 @default.
- W2904383504 hasBestOaLocation W29043835041 @default.
- W2904383504 hasConcept C104317684 @default.
- W2904383504 hasConcept C145059251 @default.
- W2904383504 hasConcept C150194340 @default.
- W2904383504 hasConcept C152724338 @default.
- W2904383504 hasConcept C2778019345 @default.
- W2904383504 hasConcept C2987395477 @default.
- W2904383504 hasConcept C502942594 @default.
- W2904383504 hasConcept C54355233 @default.
- W2904383504 hasConcept C60644358 @default.
- W2904383504 hasConcept C70721500 @default.
- W2904383504 hasConcept C86803240 @default.
- W2904383504 hasConceptScore W2904383504C104317684 @default.
- W2904383504 hasConceptScore W2904383504C145059251 @default.
- W2904383504 hasConceptScore W2904383504C150194340 @default.
- W2904383504 hasConceptScore W2904383504C152724338 @default.
- W2904383504 hasConceptScore W2904383504C2778019345 @default.
- W2904383504 hasConceptScore W2904383504C2987395477 @default.
- W2904383504 hasConceptScore W2904383504C502942594 @default.
- W2904383504 hasConceptScore W2904383504C54355233 @default.
- W2904383504 hasConceptScore W2904383504C60644358 @default.
- W2904383504 hasConceptScore W2904383504C70721500 @default.
- W2904383504 hasConceptScore W2904383504C86803240 @default.
- W2904383504 hasIssue "4" @default.
- W2904383504 hasLocation W29043835041 @default.
- W2904383504 hasOpenAccess W2904383504 @default.
- W2904383504 hasPrimaryLocation W29043835041 @default.
- W2904383504 hasRelatedWork W1996425262 @default.
- W2904383504 hasRelatedWork W2132783153 @default.
- W2904383504 hasRelatedWork W2354946581 @default.
- W2904383504 hasRelatedWork W2397034289 @default.
- W2904383504 hasRelatedWork W2513957010 @default.
- W2904383504 hasRelatedWork W2760840649 @default.
- W2904383504 hasRelatedWork W2802217527 @default.
- W2904383504 hasRelatedWork W2953373391 @default.
- W2904383504 hasRelatedWork W3031776726 @default.
- W2904383504 hasRelatedWork W4200418857 @default.
- W2904383504 hasVolume "3" @default.
- W2904383504 isParatext "false" @default.
- W2904383504 isRetracted "false" @default.
- W2904383504 magId "2904383504" @default.
- W2904383504 workType "article" @default.