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- W2904385638 abstract "Cystatin C (CysC) is a marker for estimation of glomerular filtration rate (GFR). CysC levels may depend not only on clearance/GFR but possibly also on changes in production. Our studies on tissue distribution of CysC protein in mice showed that adipose tissue expresses significant amounts of CysC, suggesting that adipocytes could contribute to circulating CysC levels in vivo. As growth hormone (GH) and triiodothyronine (T3) increase both GFR and CysC (increased in acromegaly and hyperthyroidism) in vivo, we studied whether they could increase CysC production in 3T3-L1 adipocytes in vitro. CysC accumulated in culture media of 3T3-L1 adipocytes in a time-dependent fashion. GH and T3 both (10 nmol/l) increased accumulation of CysC, to 373 ± 14 and 422 ± 20, respectively, vs 298 ± 10 ng per well over 4 days in controls. Thus, GH and T3 enhance the production of CysC by adipocytes in vitro." @default.
- W2904385638 created "2018-12-22" @default.
- W2904385638 creator A5007837138 @default.
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- W2904385638 creator A5077338751 @default.
- W2904385638 creator A5087934402 @default.
- W2904385638 creator A5090942260 @default.
- W2904385638 date "2019-02-01" @default.
- W2904385638 modified "2023-10-17" @default.
- W2904385638 title "Cystatin C in adipose tissue and stimulation of its production by growth hormone and triiodothyronine in 3T3-L1 cells" @default.
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- W2904385638 doi "https://doi.org/10.1016/j.mce.2018.12.004" @default.
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- W2904385638 hasPublicationYear "2019" @default.
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