FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904387613> ?p ?o ?g. }

• W2904387613 endingPage "3491" @default.
• W2904387613 startingPage "3483" @default.
• W2904387613 abstract "Abstract Excessive and constitutive activation of nuclear factor-κB (NF-κB) leads to abnormal cell proliferation and differentiation, leading to the development of malignant tumors, including lymphoma. MicroRNA 146a (miR-146a) and miR-146b, both of which carry an identical seed sequence, have been shown to contribute to inflammatory diseases and tumors by suppressing the expression of key molecules required for NF-κB activation. However, the functional and physiological differences between miR-146a and miR-146b in disease onset have not been fully elucidated. In this study, we generated miR-146b–knockout (KO) and miR-146a–KO mice by genome editing and found that both strains developed hematopoietic malignancies such as B-cell lymphoma and acute myeloid leukemia during aging. However, the B-cell lymphomas observed in miR-146a– and miR-146b–KO mice were histologically different in their morphology, and the malignancy rate is lower in miR-146b mice than miR-146a mice. Upon mitogenic stimulation, the expression of miR-146a and miR-146b was increased, but miR-146b expression was lower than that of miR-146a. Using a previously developed screening system for microRNA targets, we observed that miR-146a and miR-146b could target the same mRNAs, including TRAF6, and inhibit subsequent NF-κB activity. Consistent with these findings, both miR-146a– and miR-146b–KO B cells showed a high proliferative capacity. Taken together, sustained NF-κB activation in miR-146b KO mice could lead to the development of hematopoietic malignancy with aging." @default.
• W2904387613 created "2018-12-22" @default.
• W2904387613 creator A5003662106 @default.
• W2904387613 creator A5009787677 @default.
• W2904387613 creator A5027959930 @default.
• W2904387613 creator A5031476943 @default.
• W2904387613 creator A5034173750 @default.
• W2904387613 creator A5041091227 @default.
• W2904387613 creator A5060903159 @default.
• W2904387613 creator A5063353884 @default.
• W2904387613 creator A5065427229 @default.
• W2904387613 creator A5072809750 @default.
• W2904387613 creator A5076494729 @default.
• W2904387613 creator A5077847899 @default.
• W2904387613 creator A5080339510 @default.
• W2904387613 creator A5084969110 @default.
• W2904387613 creator A5089495918 @default.
• W2904387613 date "2018-12-07" @default.
• W2904387613 modified "2023-10-02" @default.
• W2904387613 title "Ablation of miR-146b in mice causes hematopoietic malignancy" @default.
• W2904387613 cites W1055070743 @default.
• W2904387613 cites W1618749171 @default.
• W2904387613 cites W1639853587 @default.
• W2904387613 cites W1825871834 @default.
• W2904387613 cites W1971659434 @default.
• W2904387613 cites W1976590012 @default.
• W2904387613 cites W1979816280 @default.
• W2904387613 cites W1992631972 @default.
• W2904387613 cites W1997338207 @default.
• W2904387613 cites W1999177172 @default.
• W2904387613 cites W2003877633 @default.
• W2904387613 cites W2007993909 @default.
• W2904387613 cites W2014581947 @default.
• W2904387613 cites W2016466834 @default.
• W2904387613 cites W2023723781 @default.
• W2904387613 cites W2031855605 @default.
• W2904387613 cites W2035135710 @default.
• W2904387613 cites W2035474025 @default.
• W2904387613 cites W2042073539 @default.
• W2904387613 cites W2045881743 @default.
• W2904387613 cites W2047648173 @default.
• W2904387613 cites W2055344766 @default.
• W2904387613 cites W2058716265 @default.
• W2904387613 cites W2059132322 @default.
• W2904387613 cites W2067257663 @default.
• W2904387613 cites W2075860675 @default.
• W2904387613 cites W2080518113 @default.
• W2904387613 cites W2098199767 @default.
• W2904387613 cites W2098270492 @default.
• W2904387613 cites W2101619948 @default.
• W2904387613 cites W2109272381 @default.
• W2904387613 cites W2109597203 @default.
• W2904387613 cites W2116382435 @default.
• W2904387613 cites W2118251998 @default.
• W2904387613 cites W2118375123 @default.
• W2904387613 cites W2129610269 @default.
• W2904387613 cites W2133613657 @default.
• W2904387613 cites W2136059996 @default.
• W2904387613 cites W2139030718 @default.
• W2904387613 cites W2144770839 @default.
• W2904387613 cites W2151622392 @default.
• W2904387613 cites W2155605501 @default.
• W2904387613 cites W2158267770 @default.
• W2904387613 cites W2162674813 @default.
• W2904387613 cites W2164840475 @default.
• W2904387613 cites W2314621992 @default.
• W2904387613 cites W2343186061 @default.
• W2904387613 cites W2508232957 @default.
• W2904387613 cites W2530648901 @default.
• W2904387613 cites W2534606192 @default.
• W2904387613 cites W2541610918 @default.
• W2904387613 cites W2601113264 @default.
• W2904387613 cites W2625850142 @default.
• W2904387613 cites W2740607174 @default.
• W2904387613 cites W2743677958 @default.
• W2904387613 cites W2817337970 @default.
• W2904387613 doi "https://doi.org/10.1182/bloodadvances.2018017954" @default.
• W2904387613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6290096" @default.
• W2904387613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30530754" @default.
• W2904387613 hasPublicationYear "2018" @default.
• W2904387613 type Work @default.
• W2904387613 sameAs 2904387613 @default.
• W2904387613 citedByCount "13" @default.
• W2904387613 countsByYear W29043876132020 @default.
• W2904387613 countsByYear W29043876132021 @default.
• W2904387613 countsByYear W29043876132022 @default.
• W2904387613 countsByYear W29043876132023 @default.
• W2904387613 crossrefType "journal-article" @default.
• W2904387613 hasAuthorship W2904387613A5003662106 @default.
• W2904387613 hasAuthorship W2904387613A5009787677 @default.
• W2904387613 hasAuthorship W2904387613A5027959930 @default.
• W2904387613 hasAuthorship W2904387613A5031476943 @default.
• W2904387613 hasAuthorship W2904387613A5034173750 @default.
• W2904387613 hasAuthorship W2904387613A5041091227 @default.
• W2904387613 hasAuthorship W2904387613A5060903159 @default.
• W2904387613 hasAuthorship W2904387613A5063353884 @default.
• W2904387613 hasAuthorship W2904387613A5065427229 @default.
• W2904387613 hasAuthorship W2904387613A5072809750 @default.

• next