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- W2904387796 abstract "CancerNeuroblastomas—the most common tumor type in infants—develop from fetal nerve cells, and their clinical course is highly variable. Some neuroblastomas are fatal despite treatment, whereas others respond well to treatment and some undergo spontaneous regression without treatment. Ackermann et al. sequenced more than 400 pretreatment neuroblastomas and identified molecular features that characterize the three distinct clinical outcomes. Low-risk tumors lack telomere maintenance mechanisms, intermediate-risk tumors harbor telomere maintenance mechanisms, and high-risk tumors harbor telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations.Science , this issue p. [1165][1] [1]: /lookup/doi/10.1126/science.aat6768" @default.
- W2904387796 created "2018-12-22" @default.
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- W2904387796 date "2018-12-06" @default.
- W2904387796 modified "2023-10-18" @default.
- W2904387796 title "A systematic look at a childhood tumor" @default.
- W2904387796 doi "https://doi.org/10.1126/science.362.6419.1124-a" @default.
- W2904387796 hasPublicationYear "2018" @default.
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