FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2904391519> ?p ?o ?g. }

• W2904391519 abstract "Multiple studies have investigated selection signatures in domestic cattle and other species. However, there is a dearth of information about the response to selection in genomes of highly admixed crossbred cattle in relation to production and adaptation to tropical environments. In this study, we evaluated 839 admixed crossbred cows sampled from two major dairy regions in Tanzania namely Rungwe and Lushoto districts, in order to understand their genetic architecture and detect genomic regions showing preferential selection. Animals were genotyped at 150,000 SNP loci using the Geneseek Genomic Profiler (GGP) High Density (HD) SNP array. Population structure analysis showed a large within-population genetic diversity in the study animals with a high degree of variation in admixture ranging between 7 and 100% taurine genes (dairyness) of mostly Holstein and Friesian ancestry. We explored evidence of selection signatures using three statistical methods (iHS, XP-EHH, and pcadapt). Selection signature analysis identified 108 candidate selection regions in the study population. Annotation of these regions yielded interesting genes potentially under strong positive selection including ABCG2, ABCC2, XKR4, LYN, TGS1, TOX, HERC6, KIT, PLAG1, CHCHD7, NCAPG, and LCORL that are involved in multiple biological pathways underlying production and adaptation processes. Several candidate selection regions showed an excess of African taurine ancestral allele dosage. Our results provide further useful insight into potential selective sweeps in the genome of admixed cattle with possible adaptive and productive importance. Further investigations will be necessary to better characterize these candidate regions with respect to their functional significance to tropical adaptations for dairy cattle." @default.
• W2904391519 created "2018-12-22" @default.
• W2904391519 creator A5004666230 @default.
• W2904391519 creator A5015690545 @default.
• W2904391519 creator A5044544424 @default.
• W2904391519 creator A5062422148 @default.
• W2904391519 creator A5076933182 @default.
• W2904391519 creator A5089681872 @default.
• W2904391519 date "2018-12-19" @default.
• W2904391519 modified "2023-10-02" @default.
• W2904391519 title "Signatures of Selection in Admixed Dairy Cattle in Tanzania" @default.
• W2904391519 cites W1539118047 @default.
• W2904391519 cites W1576934797 @default.
• W2904391519 cites W1853401073 @default.
• W2904391519 cites W1892293382 @default.
• W2904391519 cites W1964895626 @default.
• W2904391519 cites W1965051736 @default.
• W2904391519 cites W1968688547 @default.
• W2904391519 cites W1982663312 @default.
• W2904391519 cites W1984320064 @default.
• W2904391519 cites W1995303225 @default.
• W2904391519 cites W1997744353 @default.
• W2904391519 cites W1998813228 @default.
• W2904391519 cites W2005395185 @default.
• W2904391519 cites W2019794729 @default.
• W2904391519 cites W2025253353 @default.
• W2904391519 cites W2050174286 @default.
• W2904391519 cites W2068872449 @default.
• W2904391519 cites W2077946779 @default.
• W2904391519 cites W2085238796 @default.
• W2904391519 cites W2087506006 @default.
• W2904391519 cites W2088052496 @default.
• W2904391519 cites W2089893095 @default.
• W2904391519 cites W2094198395 @default.
• W2904391519 cites W2097313996 @default.
• W2904391519 cites W2098037737 @default.
• W2904391519 cites W2102213696 @default.
• W2904391519 cites W2104703917 @default.
• W2904391519 cites W2112358885 @default.
• W2904391519 cites W2115837368 @default.
• W2904391519 cites W2118484872 @default.
• W2904391519 cites W2119080840 @default.
• W2904391519 cites W2119444539 @default.
• W2904391519 cites W2122257456 @default.
• W2904391519 cites W2123707618 @default.
• W2904391519 cites W2123966658 @default.
• W2904391519 cites W2125105410 @default.
• W2904391519 cites W2126262301 @default.
• W2904391519 cites W2133097426 @default.
• W2904391519 cites W2134121494 @default.
• W2904391519 cites W2144410236 @default.
• W2904391519 cites W2147184408 @default.
• W2904391519 cites W2154804764 @default.
• W2904391519 cites W2156866331 @default.
• W2904391519 cites W2156886335 @default.
• W2904391519 cites W2159326528 @default.
• W2904391519 cites W2161633633 @default.
• W2904391519 cites W2164924658 @default.
• W2904391519 cites W2168059506 @default.
• W2904391519 cites W2168181476 @default.
• W2904391519 cites W2257611961 @default.
• W2904391519 cites W2264330092 @default.
• W2904391519 cites W2306376779 @default.
• W2904391519 cites W2317094502 @default.
• W2904391519 cites W2373966518 @default.
• W2904391519 cites W2470243530 @default.
• W2904391519 cites W2484835160 @default.
• W2904391519 cites W2577599538 @default.
• W2904391519 cites W2600644515 @default.
• W2904391519 cites W2607365361 @default.
• W2904391519 cites W2612450133 @default.
• W2904391519 cites W2622798787 @default.
• W2904391519 cites W2756472892 @default.
• W2904391519 cites W2781985431 @default.
• W2904391519 cites W2782475854 @default.
• W2904391519 cites W2788939605 @default.
• W2904391519 cites W2792623935 @default.
• W2904391519 cites W2799351006 @default.
• W2904391519 cites W2799977149 @default.
• W2904391519 cites W2888347958 @default.
• W2904391519 cites W2949231000 @default.
• W2904391519 cites W4231172525 @default.
• W2904391519 cites W784175858 @default.
• W2904391519 doi "https://doi.org/10.3389/fgene.2018.00607" @default.
• W2904391519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6305962" @default.
• W2904391519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30619449" @default.
• W2904391519 hasPublicationYear "2018" @default.
• W2904391519 type Work @default.
• W2904391519 sameAs 2904391519 @default.
• W2904391519 citedByCount "36" @default.
• W2904391519 countsByYear W29043915192020 @default.
• W2904391519 countsByYear W29043915192021 @default.
• W2904391519 countsByYear W29043915192022 @default.
• W2904391519 countsByYear W29043915192023 @default.
• W2904391519 crossrefType "journal-article" @default.
• W2904391519 hasAuthorship W2904391519A5004666230 @default.
• W2904391519 hasAuthorship W2904391519A5015690545 @default.
• W2904391519 hasAuthorship W2904391519A5044544424 @default.
• W2904391519 hasAuthorship W2904391519A5062422148 @default.
• W2904391519 hasAuthorship W2904391519A5076933182 @default.

• next