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• W2904409589 startingPage "498" @default.
• W2904409589 abstract "Synthetic biology is a rapidly developing field aimed at engineering of biological systems with predictable properties. Synthetic biology accumulates the achievements of modern biological sciences, programming and computational model­ing as well as engineering technologies for creation of biologi­cal objects with user-defined properties. Evolution of synthetic biology has been marked by a number of technological developments in each of the mentioned fields. Thus, significant reduction in cost of DNA sequencing has provided an easy access to large amounts of data on the genetic sequences of various organisms, and decreased the price of the DNA sequence synthesis, which, analogous to Moore’s law, resulted in an opportunity to create a lot of potential genes without the time – consuming and labor – intensive traditional methods of molecular biology. Development of system biology has allowed forming a deeper understanding of the functions and relationship of natural biological models, as well as of the computational models describing processes at the cell and system levels. Combination of these factors has created an op­portunity for conscious changes of natural biological systems. In this review the modern approaches to oligonucleotide gene assembly synthesis are discussed, including such aspects as protocols for gene assembly, sequence verification, error cor­rection and further applications of synthesized genes." @default.
• W2904409589 created "2018-12-22" @default.
• W2904409589 creator A5054914858 @default.
• W2904409589 creator A5080494960 @default.
• W2904409589 date "2018-08-10" @default.
• W2904409589 modified "2023-10-16" @default.
• W2904409589 title "Modern approaches to artificial gene synthesis: aspects of oligonucleotide synthesis, enzymatic assembly, sequence verification and error correction" @default.
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• W2904409589 doi "https://doi.org/10.18699/vj18.387" @default.
• W2904409589 hasPublicationYear "2018" @default.
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